Role of fetal DNA in preeclampsia (Review)

  • Authors:
    • Barbora Konečná
    • Barbora Vlková
    • Peter Celec
  • View Affiliations

  • Published online on: December 15, 2014     https://doi.org/10.3892/ijmm.2014.2039
  • Pages: 299-304
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Abstract

Preeclampsia is an autoimmune disorder characterized by hypertension. It begins with abnormal cytotrophoblast apoptosis, which leads to inflammation and an increase in the levels of anti-angiogenic factors followed by the disruption of the angiogenic status. Increased levels of fetal DNA and RNA coming from the placenta, one of the most commonly affected organs in pregnancies complicated by preeclampsia, have been found in pregnant women with the condition. However, it remains unknown as to whether this is a cause or a consequence of preeclampsia. Few studies have been carried out on preeclampsia in which an animal model of preeclampsia was induced by an injection of different types of DNA that are mimic fetal DNA and provoke inflammation through Toll-like receptor 9 (TLR9) or cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). The specific mechanisms involved in the development of preeclampsia are not yet fully understood. It is hypothesized that the presence of different fragments of fetal DNA in maternal plasma may cause for the development of preeclampsia. The function of DNase during preeclampsia also remains unresolved. Studies have suggested that its activity is decreased or the DNA is protected against its effects. Further research is required to uncover the pathogenesis of preeclampsia and focus more on the condition of patients with the condition.
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February-2015
Volume 35 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Konečná B, Vlková B and Celec P: Role of fetal DNA in preeclampsia (Review). Int J Mol Med 35: 299-304, 2015.
APA
Konečná, B., Vlková, B., & Celec, P. (2015). Role of fetal DNA in preeclampsia (Review). International Journal of Molecular Medicine, 35, 299-304. https://doi.org/10.3892/ijmm.2014.2039
MLA
Konečná, B., Vlková, B., Celec, P."Role of fetal DNA in preeclampsia (Review)". International Journal of Molecular Medicine 35.2 (2015): 299-304.
Chicago
Konečná, B., Vlková, B., Celec, P."Role of fetal DNA in preeclampsia (Review)". International Journal of Molecular Medicine 35, no. 2 (2015): 299-304. https://doi.org/10.3892/ijmm.2014.2039