let-7a and its target, insulin-like growth factor 1 receptor, are differentially expressed in recurrent prostate cancer

  • Authors:
    • Bing Tian
    • Nannan Huo
    • Meng Li
    • Yong Li
    • Zhongzhou He
  • View Affiliations

  • Published online on: September 29, 2015     https://doi.org/10.3892/ijmm.2015.2357
  • Pages: 1409-1416
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Abstract

Prostate cancer (PCa) is the most common malignancy in males worldwide. Approximately 30% of those patients who received radical prostatectomy developed clinical recurrence accompanied by elevated serum prostate‑specific antigen levels. Although knowledge regarding the development of PCa has been significantly improved, the molecular mechanism underlying recurrence remains largely unknown. The objective of the present study was to identify the differentially expressed microRNAs (miRNAs) in recurrent PCa to explore the possible involvement of miRNAs in the relapse. The expression of 6 miRs that have been previously reported to be downregulated in PCa stem cells were examined in a total of 32 recurrent and 36 non‑recurrent PCa samples, and let‑7a was substantially decreased in the recurrent PCa. Using the online prediction tools, let‑7a was identified to virtually target insulin‑like growth factor 1 receptor (IGF1R). IGF1R as a target of let‑7a was subsequently validated using the luciferase assay. Exogenous expression of let‑7a suppressed the expression of IGF1R, and reduced the proliferation of PCa cells by introducing apoptosis to the cells. In conclusion, the present data demonstrated a possible involvement of let‑7a in the pathogenesis of recurrent PCa, and it may be a potential target of the disease.
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November-2015
Volume 36 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tian B, Huo N, Li M, Li Y and He Z: let-7a and its target, insulin-like growth factor 1 receptor, are differentially expressed in recurrent prostate cancer. Int J Mol Med 36: 1409-1416, 2015
APA
Tian, B., Huo, N., Li, M., Li, Y., & He, Z. (2015). let-7a and its target, insulin-like growth factor 1 receptor, are differentially expressed in recurrent prostate cancer. International Journal of Molecular Medicine, 36, 1409-1416. https://doi.org/10.3892/ijmm.2015.2357
MLA
Tian, B., Huo, N., Li, M., Li, Y., He, Z."let-7a and its target, insulin-like growth factor 1 receptor, are differentially expressed in recurrent prostate cancer". International Journal of Molecular Medicine 36.5 (2015): 1409-1416.
Chicago
Tian, B., Huo, N., Li, M., Li, Y., He, Z."let-7a and its target, insulin-like growth factor 1 receptor, are differentially expressed in recurrent prostate cancer". International Journal of Molecular Medicine 36, no. 5 (2015): 1409-1416. https://doi.org/10.3892/ijmm.2015.2357