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Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).

  • Authors:
    • C Uneyama
    • H Uneyama
    • K Torii
    • N Akaike

  • View Affiliations

  • Published online on: August 1, 1999     https://doi.org/10.3892/ijmm.4.2.163
  • Pages: 163-172
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Megakaryocytes respond to externally applied agonists showing a periodic K+ current that reflects oscillation in cytoplasmic calcium concentration ([Ca2+]i). We have revealed several signal transducing factors that are involved in the K+ current oscillation of megakaryocytes. In this megakaryocyte system, it is relatively easy to determine what point of the signal transduction pathway a drug affects. In addition, as a progenitor cell, megakaryocytes resemble platelets which have important roles in many diseases. Therefore, this experimental system can be used for evaluation of new drugs.

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Journal Cover

Aug 1999
Volume 4 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Uneyama C, Uneyama H, Torii K and Akaike N: Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).. Int J Mol Med 4: 163-172, 1999
APA
Uneyama, C., Uneyama, H., Torii, K., & Akaike, N. (1999). Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).. International Journal of Molecular Medicine, 4, 163-172. https://doi.org/10.3892/ijmm.4.2.163
MLA
Uneyama, C., Uneyama, H., Torii, K., Akaike, N."Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).". International Journal of Molecular Medicine 4.2 (1999): 163-172.
Chicago
Uneyama, C., Uneyama, H., Torii, K., Akaike, N."Potassium-current oscillation of rat megakaryocytes: As a model system for drug evaluation (Review).". International Journal of Molecular Medicine 4, no. 2 (1999): 163-172. https://doi.org/10.3892/ijmm.4.2.163