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Divergent effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells.

  • Authors:
    • I Jamil
    • A Symonds
    • S Lynch
    • O Alalami
    • M Smyth
    • J Martin

  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/ijmm.4.3.309
  • Pages: 309-321
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

We investigated the effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells. Cells which had been treated with paracetamol (0.01 microM - 10 microM) exhibited a significant (p<0.001) increase in hydrogen peroxide production and a significant (p<0.001) increase in phorbol 12-myristate 13-acetate induced superoxide production. Conversely, paracetamol (0.01 microM - 10 microM) caused a significant (p<0.001) decrease in the amount of nitrite secreted into the culture medium. Our results indicate divergent effects of paracetamol on ROI and RNI production.

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Sep 1999
Volume 4 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Jamil I, Symonds A, Lynch S, Alalami O, Smyth M and Martin J: Divergent effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells.. Int J Mol Med 4: 309-321, 1999
APA
Jamil, I., Symonds, A., Lynch, S., Alalami, O., Smyth, M., & Martin, J. (1999). Divergent effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells.. International Journal of Molecular Medicine, 4, 309-321. https://doi.org/10.3892/ijmm.4.3.309
MLA
Jamil, I., Symonds, A., Lynch, S., Alalami, O., Smyth, M., Martin, J."Divergent effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells.". International Journal of Molecular Medicine 4.3 (1999): 309-321.
Chicago
Jamil, I., Symonds, A., Lynch, S., Alalami, O., Smyth, M., Martin, J."Divergent effects of paracetamol on reactive oxygen intermediate and reactive nitrogen intermediate production by U937 cells.". International Journal of Molecular Medicine 4, no. 3 (1999): 309-321. https://doi.org/10.3892/ijmm.4.3.309