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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Oct 1999 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Oct 1999 Volume 4 Issue 4

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Article

In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.

  • Authors:
    • S Pacor
    • R Gagliardi
    • E Di Daniel
    • M Vadori
    • G Sava

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences, University of Trieste, 34127 Trieste, Italy.
  • Pages: 369-444
    |
    Published online on: October 1, 1999
       https://doi.org/10.3892/ijmm.4.4.369
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Abstract

The aim of the present investigation was to examine the effects of the lysozyme derivative mPEG-lyso (hen egg-white lysozyme coupled with polyoxyethylenglycol), on TS/A adenocarcinoma cell line in vivo and in vitro. mPEG-lyso reduces the number of ICAM-1+ and E-cadherin+ cells of TS/A adenocarcinoma cell line in vitro, and causes a marked decrease of spontaneous lung metastases in vivo. In both cases, mPEG-lyso reduces the number of tumour cells in sythesis and pre-mitotic phases. In connection with the reduction of cells expressing adhesion molecules, mPEG-lyso reduces the number of infiltrating leukocytes in the primary tumour in vivo and reduces the binding capacity of splenocytes to tumour cells in vitro. These data stress, for the first time, that the in vivo control of mPEG-lyso on lung metastasis formation of solid metastasising tumours may be due to a combination of effects on tumour cells in addition to those on host's immune system.

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Copy and paste a formatted citation
Spandidos Publications style
Pacor S, Gagliardi R, Di Daniel E, Vadori M and Sava G: In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.. Int J Mol Med 4: 369-444, 1999.
APA
Pacor, S., Gagliardi, R., Di Daniel, E., Vadori, M., & Sava, G. (1999). In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.. International Journal of Molecular Medicine, 4, 369-444. https://doi.org/10.3892/ijmm.4.4.369
MLA
Pacor, S., Gagliardi, R., Di Daniel, E., Vadori, M., Sava, G."In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.". International Journal of Molecular Medicine 4.4 (1999): 369-444.
Chicago
Pacor, S., Gagliardi, R., Di Daniel, E., Vadori, M., Sava, G."In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.". International Journal of Molecular Medicine 4, no. 4 (1999): 369-444. https://doi.org/10.3892/ijmm.4.4.369
Copy and paste a formatted citation
x
Spandidos Publications style
Pacor S, Gagliardi R, Di Daniel E, Vadori M and Sava G: In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.. Int J Mol Med 4: 369-444, 1999.
APA
Pacor, S., Gagliardi, R., Di Daniel, E., Vadori, M., & Sava, G. (1999). In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.. International Journal of Molecular Medicine, 4, 369-444. https://doi.org/10.3892/ijmm.4.4.369
MLA
Pacor, S., Gagliardi, R., Di Daniel, E., Vadori, M., Sava, G."In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.". International Journal of Molecular Medicine 4.4 (1999): 369-444.
Chicago
Pacor, S., Gagliardi, R., Di Daniel, E., Vadori, M., Sava, G."In vitro down regulation of ICAM-1 and E-cadherin and in vivo reduction of lung metastases of TS/A adenocarcinoma by a lysozyme derivative.". International Journal of Molecular Medicine 4, no. 4 (1999): 369-444. https://doi.org/10.3892/ijmm.4.4.369
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