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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Dec 1999 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Dec 1999 Volume 4 Issue 6

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Article

Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.

  • Authors:
    • L C Lim
    • K K Heng
    • M Vellupillai
    • L T Tan
    • B C Boey
    • L C Lau
    • G F How

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Singapore General Hospital, Singapore 169608, Republic of Singapore.
  • Pages: 665-672
    |
    Published online on: December 1, 1999
       https://doi.org/10.3892/ijmm.4.6.665
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Abstract

The Philadelphia chromosome is present in a heterogeneous group of leukemias. It is most commonly associated with chronic myelogenous leukemia (CML) and B-lineage acute lymphoblastic leukemia (ALL) being found in more than 95% and 15-25% of cases respectively. We undertook a study to determine the morphologic, phenotypic and molecular diversity of Philadelphia positive de novo acute leukemia patients seen at our institution over the past 3 1/2 years. Twenty-one patients with de novo acute leukemia were found to have the Philadelphia chromosome by cytogenetic studies. They consisted of 3 patients with acute myelogenous leukemia (AML), 1 biphenotypic leukemia and 17 ALL patients. Of the patients with ALL, 16 were of B-lineage while 1 had a T-cell phenotype. Ten patients expressed the p210 BCR-ABL transcript alone and 10 expressed only the p190 BCR-ABL transcript. One patient had co-expression of p190 and p210 b3a2 BCR-ABL transcripts. Thus the Philadelphia chromosome can be found in a diverse cohort of morphologic and immunologic subtypes of de novo acute leukemia reflecting the heterogeneity of lineage involvement in this disease.

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Copy and paste a formatted citation
Spandidos Publications style
Lim L, Heng K, Vellupillai M, Tan L, Boey B, Lau L and How G: Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.. Int J Mol Med 4: 665-672, 1999.
APA
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., & How, G. (1999). Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.. International Journal of Molecular Medicine, 4, 665-672. https://doi.org/10.3892/ijmm.4.6.665
MLA
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., How, G."Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.". International Journal of Molecular Medicine 4.6 (1999): 665-672.
Chicago
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., How, G."Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.". International Journal of Molecular Medicine 4, no. 6 (1999): 665-672. https://doi.org/10.3892/ijmm.4.6.665
Copy and paste a formatted citation
x
Spandidos Publications style
Lim L, Heng K, Vellupillai M, Tan L, Boey B, Lau L and How G: Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.. Int J Mol Med 4: 665-672, 1999.
APA
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., & How, G. (1999). Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.. International Journal of Molecular Medicine, 4, 665-672. https://doi.org/10.3892/ijmm.4.6.665
MLA
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., How, G."Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.". International Journal of Molecular Medicine 4.6 (1999): 665-672.
Chicago
Lim, L., Heng, K., Vellupillai, M., Tan, L., Boey, B., Lau, L., How, G."Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia.". International Journal of Molecular Medicine 4, no. 6 (1999): 665-672. https://doi.org/10.3892/ijmm.4.6.665
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