Open Access

Internal driving factors leading to extrahepatic manifestation of the hepatitis C virus infection

  • Authors:
    • Zhou-Yi Wu
    • Jian-Rui Li
    • Meng-Hao Huang
    • Jun-Jun Cheng
    • Hu Li
    • Jin-Hua Chen
    • Xiao-Qin Lv
    • Zong-Gen Peng
    • Jian-Dong Jiang
  • View Affiliations

  • Published online on: October 5, 2017     https://doi.org/10.3892/ijmm.2017.3175
  • Pages:1792-1802
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, which are correlated with poor outcomes, and thus increase the morbidity and mortality of chronic hepatitis C (CHC). Therefore, understanding the internal linkages between systemic manifestations and HCV infection is helpful for treatment of CHC. Yet, the mechanism by which the virus evokes the systemic diseases remains to be elucidated. In the present study, using gene set enrichment analysis (GSEA) and signaling pathway impact analysis (SPIA), a comprehensive analysis of microarray data of mRNAs was conducted in HCV-infected and -uninfected Huh7.5 cells, and signaling pathways (which are significantly activated or inhibited) and certain molecules (which are commonly important in those signaling pathways) were selected. Forty signaling pathways were selected using GSEA, and eight signaling pathways were selected with SPIA. These pathways are associated with cancer, metabolism, environmental information processing and organismal systems, which provide important information for further clarifying the intrinsic associations between syndromes of HCV infection, of which seven pathways were not previously reported, including basal transcription factors, pathogenic Escherichia coli infection, shigellosis, gastric acid secretion, dorso-ventral axis formation, amoebiasis and cholinergic synapse. Ten genes, SOS1, RAF1, IFNA2, IFNG, MTHFR, IGF1, CALM3, UBE2B, TP53 and BMP7 whose expression may be the key internal driving molecules, were selected using the online tool Anni 2.1. Furthermore, the present study demonstrated the internal linkages between systemic manifestations and HCV infection, and presented the potential molecules that are key to those linkages.

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December 2017
Volume 40 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2016 Impact Factor: 2.341
Ranked #21/128 Medicine Research and Experimental
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Copy and paste a formatted citation
APA
Wu, Z., Li, J., Huang, M., Cheng, J., Li, H., Chen, J. ... Jiang, J. (2017). Internal driving factors leading to extrahepatic manifestation of the hepatitis C virus infection. International Journal of Molecular Medicine, 40, 1792-1802. https://doi.org/10.3892/ijmm.2017.3175
MLA
Wu, Z., Li, J., Huang, M., Cheng, J., Li, H., Chen, J., Lv, X., Peng, Z., Jiang, J."Internal driving factors leading to extrahepatic manifestation of the hepatitis C virus infection". International Journal of Molecular Medicine 40.6 (2017): 1792-1802.
Chicago
Wu, Z., Li, J., Huang, M., Cheng, J., Li, H., Chen, J., Lv, X., Peng, Z., Jiang, J."Internal driving factors leading to extrahepatic manifestation of the hepatitis C virus infection". International Journal of Molecular Medicine 40, no. 6 (2017): 1792-1802. https://doi.org/10.3892/ijmm.2017.3175