Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.

  • Authors:
    • G Su
    • G Casey
    • J K Cowell
  • View Affiliations

  • Published online on: February 1, 2000     https://doi.org/10.3892/ijmm.5.2.197
  • Pages: 197-397
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Loss of heterozygosity (LOH) in 1p31 is a frequent genetic alteration in breast tumors indicating the site of a tumor suppressor gene. We recently isolated a new member of the human tetratricopeptide repeat-containing family of genes, TTC4, which maps to this region. Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. We now report the exon/intron structure of TTC4 and single strand conformation polymorphism (SSCP) analysis of DNA from 20 sporadic breast tumors. Although polymorphic variations were identified no mutations affecting the open reading frame of TTC4 were detected. Since the overall region of chromosome 1p31 which undergoes LOH can be relatively large, excluding involvement of newly isolated genes from this region in breast cancer tumorigenesis is an important process for the successful identification of the critical gene. Understanding the structure of TTC4 now makes mutation analysis possible for other cancers and diseases that map to this region.

Related Articles

Journal Cover

Feb 2000
Volume 5 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Su G, Casey G and Cowell J: Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.. Int J Mol Med 5: 197-397, 2000
APA
Su, G., Casey, G., & Cowell, J. (2000). Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.. International Journal of Molecular Medicine, 5, 197-397. https://doi.org/10.3892/ijmm.5.2.197
MLA
Su, G., Casey, G., Cowell, J."Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.". International Journal of Molecular Medicine 5.2 (2000): 197-397.
Chicago
Su, G., Casey, G., Cowell, J."Genomic structure of the human tetratricopeptide repeat-containing gene, TTC4, from chromosome region 1p31 and mutation analysis in breast cancers.". International Journal of Molecular Medicine 5, no. 2 (2000): 197-397. https://doi.org/10.3892/ijmm.5.2.197