Estrogen receptor variants are present in many normal human tissues.

  • Authors:
    • J Yang
    • A Liu
    • S K Chiou
    • R Guzman
    • S Nandi
  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/ijmm.5.3.223
  • Pages: 223-230
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Abstract

Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type and variant receptors from normal human tissues of various origin using semi-nested PCR and direct automated sequence of the amplified products. We demonstrate that many normal human tissues of various origin contain a number of spliced variants of the estrogen receptor that co-exist with the wild-type receptor. Variants lacking exons 2, 4, 5, and 7 are detected in a variety of normal human tissues.

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Mar 2000
Volume 5 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yang J, Liu A, Chiou S, Guzman R and Nandi S: Estrogen receptor variants are present in many normal human tissues.. Int J Mol Med 5: 223-230, 2000
APA
Yang, J., Liu, A., Chiou, S., Guzman, R., & Nandi, S. (2000). Estrogen receptor variants are present in many normal human tissues.. International Journal of Molecular Medicine, 5, 223-230. https://doi.org/10.3892/ijmm.5.3.223
MLA
Yang, J., Liu, A., Chiou, S., Guzman, R., Nandi, S."Estrogen receptor variants are present in many normal human tissues.". International Journal of Molecular Medicine 5.3 (2000): 223-230.
Chicago
Yang, J., Liu, A., Chiou, S., Guzman, R., Nandi, S."Estrogen receptor variants are present in many normal human tissues.". International Journal of Molecular Medicine 5, no. 3 (2000): 223-230. https://doi.org/10.3892/ijmm.5.3.223