Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.

  • Authors:
    • M Tanaka
    • T Yamazaki
    • N Araki
    • H Yoshikawa
    • T Yoshida
    • T Sakakura
    • A Uchida
  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/ijmm.5.5.505
  • Pages: 505-515
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Abstract

Tenascin-C (TN-C) is one of extracellular matrix glycoproteins. We have immunohistochemically examined the TN-C expression of 33 primary osteosarcoma paraffin-embedded samples. The TN-C expression of the patient group with metastases was higher than that of the group without metastases at significant difference, and the survival curves show a tendency for poor outcome in the high grade staining group. Moreover, the supplemental TN-C had an effect of easier migration of a human osteosarcoma cell line (HOS) in vitro. The results may suggest that TN-C help osteosarcoma cells to migrate and to metastasize.

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May 2000
Volume 5 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tanaka M, Yamazaki T, Araki N, Yoshikawa H, Yoshida T, Sakakura T and Uchida A: Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.. Int J Mol Med 5: 505-515, 2000
APA
Tanaka, M., Yamazaki, T., Araki, N., Yoshikawa, H., Yoshida, T., Sakakura, T., & Uchida, A. (2000). Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.. International Journal of Molecular Medicine, 5, 505-515. https://doi.org/10.3892/ijmm.5.5.505
MLA
Tanaka, M., Yamazaki, T., Araki, N., Yoshikawa, H., Yoshida, T., Sakakura, T., Uchida, A."Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.". International Journal of Molecular Medicine 5.5 (2000): 505-515.
Chicago
Tanaka, M., Yamazaki, T., Araki, N., Yoshikawa, H., Yoshida, T., Sakakura, T., Uchida, A."Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.". International Journal of Molecular Medicine 5, no. 5 (2000): 505-515. https://doi.org/10.3892/ijmm.5.5.505