Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.

  • Authors:
    • G A Martins
    • C R Gattas
    • M G da Costa Carvalho
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  • Published online on: May 1, 2000     https://doi.org/10.3892/ijmm.5.5.511
  • Pages: 511-514
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Abstract

Understanding how free DNA might act as a signal between cells is important for knowing how DNA orchestrates immune responses and for optimizing the therapeutic of cancer, infection and immunologic diseases. This communication demonstrates that DNAs from different origins (bacteria, T. cruzi, HeLa cells) and synthetic oligonucleotide containing an unmethylated CpG motif are capable of inducing alterations in the protein profile of normal human leukocytes. As far as we know there have been no similar studies regarding the comparative effects of different free DNAs on early protein synthesis of human peripheral blood mononuclear cells.

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May 2000
Volume 5 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Martins G, Gattas C and da Costa Carvalho M: Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.. Int J Mol Med 5: 511-514, 2000
APA
Martins, G., Gattas, C., & da Costa Carvalho, M. (2000). Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.. International Journal of Molecular Medicine, 5, 511-514. https://doi.org/10.3892/ijmm.5.5.511
MLA
Martins, G., Gattas, C., da Costa Carvalho, M."Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.". International Journal of Molecular Medicine 5.5 (2000): 511-514.
Chicago
Martins, G., Gattas, C., da Costa Carvalho, M."Free DNA induces modification on the protein synthesis profile of human peripheral blood mononuclear cells of healthy donors.". International Journal of Molecular Medicine 5, no. 5 (2000): 511-514. https://doi.org/10.3892/ijmm.5.5.511