Adeno-associated viral vectors as gene delivery vehicles.

  • Authors:
    • P J Carter
    • R J Samulski
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/ijmm.6.1.17
  • Pages: 17-44
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Abstract

Adeno-associated virus (AAV), a non-pathogenic human parvovirus, is gaining attention for its potential use as a human gene therapy vector. One of the most attractive features of recombinant AAV vectors is the ability to be stably maintained in host cells as integrated proviruses. This property is particularly desireable for therapies requiring long-term correction of a genetic defect. This review highlights recent advances made in the AAV field and will discuss some limitations of rAAV vector integration. A novel method for enhancing the integration efficiency of these vectors will be presented.

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Jul 2000
Volume 6 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Carter P and Carter P: Adeno-associated viral vectors as gene delivery vehicles.. Int J Mol Med 6: 17-44, 2000
APA
Carter, P., & Carter, P. (2000). Adeno-associated viral vectors as gene delivery vehicles.. International Journal of Molecular Medicine, 6, 17-44. https://doi.org/10.3892/ijmm.6.1.17
MLA
Carter, P., Samulski, R."Adeno-associated viral vectors as gene delivery vehicles.". International Journal of Molecular Medicine 6.1 (2000): 17-44.
Chicago
Carter, P., Samulski, R."Adeno-associated viral vectors as gene delivery vehicles.". International Journal of Molecular Medicine 6, no. 1 (2000): 17-44. https://doi.org/10.3892/ijmm.6.1.17