Binding of topo I to PARP I - antibody immunocomplex.

  • Authors:
    • P I Bauer
    • E Kun
  • View Affiliations

  • Published online on: August 1, 2000     https://doi.org/10.3892/ijmm.6.2.153
  • Pages: 153-157
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Abstract

It is frequently quoted in the literature that the cellular role of PARP I is its participation in the recognition of single strand breaks of genomic DNA (l.c.1). Although there is little doubt that PARP I can be made to respond powerfully as an factor in the recognition of DNA damage, it seems unlikely that this auxilliary, or telelogically defined, role of this highly abundant nuclear protein exhausts its physiologic cellular function. We have reported that Topo I is greatly activated by its association with PARP I (J Mol Med 5: 533-540, 2000). Translation of this in vitro model experiments to physiologic conditions was accomplished by the demonstration of the quantitative binding of Topo I to a PARP I - antibody complex, as reported here. This experiment demonstrates for the first time that the colligative action of PARP I can regulate a highly significant cellular process, the control of readability of genomic DNA, i.e., gene expression, without the artificiality of induced DNA damage.

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Aug 2000
Volume 6 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Bauer P and Kun E: Binding of topo I to PARP I - antibody immunocomplex.. Int J Mol Med 6: 153-157, 2000.
APA
Bauer, P., & Kun, E. (2000). Binding of topo I to PARP I - antibody immunocomplex.. International Journal of Molecular Medicine, 6, 153-157. https://doi.org/10.3892/ijmm.6.2.153
MLA
Bauer, P., Kun, E."Binding of topo I to PARP I - antibody immunocomplex.". International Journal of Molecular Medicine 6.2 (2000): 153-157.
Chicago
Bauer, P., Kun, E."Binding of topo I to PARP I - antibody immunocomplex.". International Journal of Molecular Medicine 6, no. 2 (2000): 153-157. https://doi.org/10.3892/ijmm.6.2.153