The CD81 expression in liver in hepatocellular carcinoma.

  • Authors:
    • G Inoue
    • N Horiike
    • M Onji
  • View Affiliations

  • Published online on: January 1, 2001     https://doi.org/10.3892/ijmm.7.1.67
  • Pages: 67-138
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Abstract

The expression of CD81, a cell receptor for hepatitis C virus, was examined on cancer cells in hepatocellular carcinoma (HCC) C (n=29) to clarify its clinical role. CD81 was expressed on hepatocyte membrane in non-tumor portions in all patients, however, this was not stained on the cancer cell membranes in 6 of 29. Reverse transcriptase-PCR revealed that CD81 gene expression was not detected in the tumorous portions in 3 of 7 samples. The loss of CD81 was prominent in poorly differentiated HCC (5 of 8) and extrahepatic metastasis patients (6 of 8). The loss of CD81 is associated with differentiation and metastasis of HCC.

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January 2001
Volume 7 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Inoue G, Horiike N and Onji M: The CD81 expression in liver in hepatocellular carcinoma.. Int J Mol Med 7: 67-138, 2001
APA
Inoue, G., Horiike, N., & Onji, M. (2001). The CD81 expression in liver in hepatocellular carcinoma.. International Journal of Molecular Medicine, 7, 67-138. https://doi.org/10.3892/ijmm.7.1.67
MLA
Inoue, G., Horiike, N., Onji, M."The CD81 expression in liver in hepatocellular carcinoma.". International Journal of Molecular Medicine 7.1 (2001): 67-138.
Chicago
Inoue, G., Horiike, N., Onji, M."The CD81 expression in liver in hepatocellular carcinoma.". International Journal of Molecular Medicine 7, no. 1 (2001): 67-138. https://doi.org/10.3892/ijmm.7.1.67