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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2001 Volume 8 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2001 Volume 8 Issue 2

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Article

Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats

  • Authors:
    • A. Sener
    • L. Ladriere
    • W. J. Malaisse
  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Medicine, Brussels Free University, B-1070 Brussels, Belgium
  • Pages: 177-180
    |
    Published online on: August 1, 2001
       https://doi.org/10.3892/ijmm.8.2.177
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Abstract

The uptake of D-[3H]mannoheptulose by isolated pancreatic islets was recently proposed as a tool to assess the relative contribution of insulin-producing cells to the total mass of the islets. In the present study, the uptake of the tritiated heptose over 60 min incubation at 37°C was about 21% lower in islets from hereditarily diabetic rats (GK rats) than in islets from control animals, this decrease being virtually identical to that documented previously by morphometric analysis of islets from the same type of rats. The intracellular 3HOH space and extracellular [U-14C]sucrose space were not significantly different in control and diabetic rats, at least when the comparison was restricted to animals of the same sex. There was a trend, however, towards a somewhat lower D-[5-3H]-glucose intracellular distribution space in islets from GK rats, as compared to control animals. These findings provide further support to the validity of D-[3H]mannoheptulose uptake as a tool to assess the density of insulin-producing cells in isolated islets.

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Copy and paste a formatted citation
Spandidos Publications style
Sener A, Ladriere L and Malaisse WJ: Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats. Int J Mol Med 8: 177-180, 2001.
APA
Sener, A., Ladriere, L., & Malaisse, W.J. (2001). Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats. International Journal of Molecular Medicine, 8, 177-180. https://doi.org/10.3892/ijmm.8.2.177
MLA
Sener, A., Ladriere, L., Malaisse, W. J."Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats". International Journal of Molecular Medicine 8.2 (2001): 177-180.
Chicago
Sener, A., Ladriere, L., Malaisse, W. J."Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats". International Journal of Molecular Medicine 8, no. 2 (2001): 177-180. https://doi.org/10.3892/ijmm.8.2.177
Copy and paste a formatted citation
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Spandidos Publications style
Sener A, Ladriere L and Malaisse WJ: Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats. Int J Mol Med 8: 177-180, 2001.
APA
Sener, A., Ladriere, L., & Malaisse, W.J. (2001). Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats. International Journal of Molecular Medicine, 8, 177-180. https://doi.org/10.3892/ijmm.8.2.177
MLA
Sener, A., Ladriere, L., Malaisse, W. J."Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats". International Journal of Molecular Medicine 8.2 (2001): 177-180.
Chicago
Sener, A., Ladriere, L., Malaisse, W. J."Assessment by D-[3H]mannoheptulose uptake of B-cell density in isolated pancreatic islets from Goto-Kakizaki rats". International Journal of Molecular Medicine 8, no. 2 (2001): 177-180. https://doi.org/10.3892/ijmm.8.2.177
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