Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland

  • Authors:
    • Cinzia Tortorella
    • Carlo Macchi
    • Myriam Forneris
    • Gastone G. Nussdorfer
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/ijmm.8.3.261
  • Pages: 261-264
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Abstract

Calcitonin gene-related peptide (CGRP) is a potent hypotensive peptide, that acts via two main subtypes of receptors, named CGRP1 and CGRP2. CGRP belongs to a regulatory-peptide family, that includes adrenomedullin (ADM) whose aldosterone antisecretagogue and catecholamine secretagogue actions are well demonstrated. Quantitative autoradiography showed the presence of [125I]CGRP binding sites in both rat adrenal zona glomerulosa (ZG) and medulla. Binding was displaced by the CGRP1-receptor antagonist CGRP(8-37), but not by the CGRP2-receptor agonist [cys(Et)2,7]-αCGRP (CGRP2-A). CGRP concentration-dependently inhibited 10 mM-stimulated (but not basal) aldosterone secretion from dispersed rat ZG cells, and enhanced basal catecholamine secretion from rat adrenomedullary fragments. The responses to the maximal effective concentration of CGRP (10-8 M) were blocked by 10-7 M CGRP(8-37). CGRP2-A (10-7 M) neither altered aldosterone response to 10 mM K+ nor enhanced basal catecholamine secretion. The conclusion is drawn that CGRP, like ADM, inhibits agonist-stimulated aldosterone secretion and stimulates basal catecholamine release in the rat, exclusively acting via CGRP1 receptors.

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September 2001
Volume 8 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tortorella C, Macchi C, Forneris M and Nussdorfer GG: Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland. Int J Mol Med 8: 261-264, 2001
APA
Tortorella, C., Macchi, C., Forneris, M., & Nussdorfer, G.G. (2001). Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland. International Journal of Molecular Medicine, 8, 261-264. https://doi.org/10.3892/ijmm.8.3.261
MLA
Tortorella, C., Macchi, C., Forneris, M., Nussdorfer, G. G."Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland". International Journal of Molecular Medicine 8.3 (2001): 261-264.
Chicago
Tortorella, C., Macchi, C., Forneris, M., Nussdorfer, G. G."Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland". International Journal of Molecular Medicine 8, no. 3 (2001): 261-264. https://doi.org/10.3892/ijmm.8.3.261