Human herpesvirus 8 DNA in HIV-negative Japanese patients with multicentric Castleman's disease and related diseases

  • Authors:
    • S. Tohda
    • N. Murakami
    • N. Nara
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/ijmm.8.5.549
  • Pages: 549-551
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Abstract

Multicentric Castleman's disease (MCD) is a lymphoproliferative disorder characterized by systemic lymphadenopathy and hypergammaglobulinemia. Recently, a French group reported that human herpesvirus 8 (HHV8) DNA was detected in tissue samples of MCD patients. The detection rate was especially high in human immunodeficiency virus (HIV)-positive MCD patients. Thus, HHV8 infection seems to be closely related to HIV infection. In Japan, the HIV infection rate in the general population is very low. To examine whether HHV8 is actually related to MCD in Japan, we performed nested polymerase chain reaction for the HHV8 genome using DNA samples from 7 patients with MCD and 23 patients with related diseases such as POEMS syndrome, amyloidosis, myeloma and lymphoma. They were all HIV-negative Japanese. Three of 7 MCD patients were positive for HHV8. There were no clear differences in clinical characteristics between HHV8-positive patients and negative ones. All other patients were negative for HHV8. Thus, we have shown that some MCD patients in Japan are also infected with HHV8.

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November 2001
Volume 8 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tohda S, Murakami N and Nara N: Human herpesvirus 8 DNA in HIV-negative Japanese patients with multicentric Castleman's disease and related diseases. Int J Mol Med 8: 549-551, 2001
APA
Tohda, S., Murakami, N., & Nara, N. (2001). Human herpesvirus 8 DNA in HIV-negative Japanese patients with multicentric Castleman's disease and related diseases. International Journal of Molecular Medicine, 8, 549-551. https://doi.org/10.3892/ijmm.8.5.549
MLA
Tohda, S., Murakami, N., Nara, N."Human herpesvirus 8 DNA in HIV-negative Japanese patients with multicentric Castleman's disease and related diseases". International Journal of Molecular Medicine 8.5 (2001): 549-551.
Chicago
Tohda, S., Murakami, N., Nara, N."Human herpesvirus 8 DNA in HIV-negative Japanese patients with multicentric Castleman's disease and related diseases". International Journal of Molecular Medicine 8, no. 5 (2001): 549-551. https://doi.org/10.3892/ijmm.8.5.549