Molecular bases for the anti-parasitic effect of NO (Review)
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- Published online on: February 1, 2002 https://doi.org/10.3892/ijmm.9.2.131
- Pages: 131-134
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Abstract
Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO.