RelA suppresses the Wnt/β-catenin pathway without exerting trans-acting transcriptional ability
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- Published online on: May 1, 2002 https://doi.org/10.3892/ijmm.9.5.489
- Pages: 489-493
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Abstract
Several cellular signaling systems exhibit cross talk. Cross talk seems to play an important role in modifying signal effects. In vertebrates, the nuclear factor κ B (NF-κB) signaling pathway plays important roles in immune response, inflammation and apoptosis. Meanwhile, the Wnt/β-catenin signaling pathway is involved in oncogenesis and development. We show here that RelA, a component of NF-κB, specifically suppressed β-catenin/Tcf-dependent transcription. This suppression did not depend on the trans-acting transcriptional ability of RelA. Furthermore, RelA neither affected the nuclear import of β-catenin nor the DNA binding ability of the β-catenin/Tcf complex, suggesting that NF-κB modifies this signaling pathway after the binding of the β-catenin/Tcf complex with target DNA.
