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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1992 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1992 Volume 1 Issue 2

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Article

BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA

  • Authors:
    • M BRYANS
    • JM LUCAS
    • NM WILKIE
    • K BURROW
    • AM CLARK
    • JC LANG

  • View Affiliations / Copyright

    Affiliations: ARTHUR G JAMES CANC HOSP & RES INST,ROOM 1248,300 W 10TH AVE,COLUMBUS,OH 43210. BEATSON INST CANC RES,GLASGOW G61 1BD,SCOTLAND.
  • Pages: 175-180
    |
    Published online on: July 1, 1992
       https://doi.org/10.3892/ijo.1.2.175
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Abstract

In Burkitt's lymphoma (BL) a consistent chromosomal translocation involving the c-myc proto-oncogene locus on chromosome 8 and one of the immunoglobulin loci located on chromosomes 14, 22 or 2 results in the aberrant expression of c-myc. In six out of ten published BL sequences the translocated c-myc gene contains mutations and/or deletions in an Spl site in the first exon. We show by competition gel mobility shift assays and association constant comparison that the binding of Spl to this site is altered in four of these clones. The affinity of Spl for this site is increased 5-10 fold in Burkitt's lymphoma BL22 and decreased approximately 5 fold in BL2. Mutations at this site in cell lines Raji and Daudi also show a decrease in Sp1 binding when compared with the wild type sequence.

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Copy and paste a formatted citation
Spandidos Publications style
BRYANS M, LUCAS J, WILKIE N, BURROW K, CLARK A and LANG J: BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA. Int J Oncol 1: 175-180, 1992.
APA
BRYANS, M., LUCAS, J., WILKIE, N., BURROW, K., CLARK, A., & LANG, J. (1992). BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA. International Journal of Oncology, 1, 175-180. https://doi.org/10.3892/ijo.1.2.175
MLA
BRYANS, M., LUCAS, J., WILKIE, N., BURROW, K., CLARK, A., LANG, J."BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA". International Journal of Oncology 1.2 (1992): 175-180.
Chicago
BRYANS, M., LUCAS, J., WILKIE, N., BURROW, K., CLARK, A., LANG, J."BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA". International Journal of Oncology 1, no. 2 (1992): 175-180. https://doi.org/10.3892/ijo.1.2.175
Copy and paste a formatted citation
x
Spandidos Publications style
BRYANS M, LUCAS J, WILKIE N, BURROW K, CLARK A and LANG J: BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA. Int J Oncol 1: 175-180, 1992.
APA
BRYANS, M., LUCAS, J., WILKIE, N., BURROW, K., CLARK, A., & LANG, J. (1992). BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA. International Journal of Oncology, 1, 175-180. https://doi.org/10.3892/ijo.1.2.175
MLA
BRYANS, M., LUCAS, J., WILKIE, N., BURROW, K., CLARK, A., LANG, J."BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA". International Journal of Oncology 1.2 (1992): 175-180.
Chicago
BRYANS, M., LUCAS, J., WILKIE, N., BURROW, K., CLARK, A., LANG, J."BINDING OF TRANSCRIPTION FACTOR SP1 TO EXON-1 OF C-MYC IS ALTERED IN BURKITTS-LYMPHOMA". International Journal of Oncology 1, no. 2 (1992): 175-180. https://doi.org/10.3892/ijo.1.2.175
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