CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH

  • Authors:
    • DM BORTNER
    • M ULIVI
    • MC OSTROWSKI
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  • Published online on: July 1, 1992     https://doi.org/10.3892/ijo.1.2.221
  • Pages: 221-225
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Abstract

To begin to understand how ras p21 might be coupled to the human colony stimulating factor-1 receptor (CSF-IR), we compared the signaling properties of a CSF-IR containing a point mutation that converts the tyrosine at position 809 to a phenylalanine residue to signal transduction in cells that co-express the wild-type receptor and the catalytic domain of the GTPase activating protein (GAP(C)). We find that modulation of the immediate early gene c-myc and a delayed early response represented by the retrotransposon NVL3 were selectively impaired in both situations. Further, constitutive expression of c-myc in cells that contain GAP(C) restored CSF-1-dependent signal transduction. The data suggest a model in which information important for mitogenic cell.growth flows from the region of the receptor containing tyrosine 809, through ras p21, to c-myc in the nucleus.

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July 1992
Volume 1 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BORTNER D, ULIVI M and OSTROWSKI M: CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH. Int J Oncol 1: 221-225, 1992.
APA
BORTNER, D., ULIVI, M., & OSTROWSKI, M. (1992). CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH. International Journal of Oncology, 1, 221-225. https://doi.org/10.3892/ijo.1.2.221
MLA
BORTNER, D., ULIVI, M., OSTROWSKI, M."CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH". International Journal of Oncology 1.2 (1992): 221-225.
Chicago
BORTNER, D., ULIVI, M., OSTROWSKI, M."CONSTITUTIVE EXPRESSION OF C-MYC IN NIH 3T3 CELLS WHICH COEXPRESS THE COLONY STIMULATING FACTOR-I RECEPTOR AND THE CATALYTIC DOMAIN OF THE GTPASE-ACTIVATING PROTEIN RESTORES COLONY STIMULATING FACTOR-I DEPENDENT MITOGENIC GROWTH". International Journal of Oncology 1, no. 2 (1992): 221-225. https://doi.org/10.3892/ijo.1.2.221