OVER-EXPRESSION OF CELLULAR ONCOGENES IN CYSTADENOCARCINOMAS OF THE OVARY

  • Authors:
    • T DINGERMANN
    • A LEIPOLD
    • S LANDGRAF
    • E GEBHART
    • AH TULUSAN
    • W KERSTEN
  • View Affiliations

  • Published online on: August 1, 1992     https://doi.org/10.3892/ijo.1.3.347
  • Pages: 347-352
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Abstract

A complex analysis of oncogene over-expression in ovarian cystadenocarcinomas of 20 patients was performed. Radioactively labelled cDNAs were synthesized from total cellular RNA from tumor cells and hybridized to dot blot filters. On each filter more than 20 different plasmids containing cloned oncogene fragments were immobilized. In concordance with published data fms was found over-expressed in 40% of the tumors. Elevated expression levels of the EGF receptor was also frequently detected. 35% of the tumors showed elevated N-ras mRNA levels. All those tumors' showed a highly dedifferentiated phenotype and were classified as G3-tumors. More over, simultaneous over-expression of different oncogenes correlated surprisingly strongly with tumor grading.

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August 1992
Volume 1 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
DINGERMANN T, LEIPOLD A, LANDGRAF S, GEBHART E, TULUSAN A and KERSTEN W: OVER-EXPRESSION OF CELLULAR ONCOGENES IN CYSTADENOCARCINOMAS OF THE OVARY. Int J Oncol 1: 347-352, 1992.
APA
DINGERMANN, T., LEIPOLD, A., LANDGRAF, S., GEBHART, E., TULUSAN, A., & KERSTEN, W. (1992). OVER-EXPRESSION OF CELLULAR ONCOGENES IN CYSTADENOCARCINOMAS OF THE OVARY. International Journal of Oncology, 1, 347-352. https://doi.org/10.3892/ijo.1.3.347
MLA
DINGERMANN, T., LEIPOLD, A., LANDGRAF, S., GEBHART, E., TULUSAN, A., KERSTEN, W."OVER-EXPRESSION OF CELLULAR ONCOGENES IN CYSTADENOCARCINOMAS OF THE OVARY". International Journal of Oncology 1.3 (1992): 347-352.
Chicago
DINGERMANN, T., LEIPOLD, A., LANDGRAF, S., GEBHART, E., TULUSAN, A., KERSTEN, W."OVER-EXPRESSION OF CELLULAR ONCOGENES IN CYSTADENOCARCINOMAS OF THE OVARY". International Journal of Oncology 1, no. 3 (1992): 347-352. https://doi.org/10.3892/ijo.1.3.347