CYCLIC AMP-RESPONSIVE GENE-TRANSCRIPTION IN CELLULAR PROLIFERATION AND TRANSFORMATION

  • Authors:
    • L MIROSSAY
    • E CHASTRE
    • S EMPEREUR
    • C GESPACH
  • View Affiliations

  • Published online on: August 1, 1992     https://doi.org/10.3892/ijo.1.3.373
  • Pages: 373-385
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Abstract

The proteins binding the cAMP responsive elements constitute a family of transcription factors (e.g. CREB 327/341, ATF, HB16, CREM) which operate as dimers and regulate positively and negatively gene expression upon interaction with the cAMP responsive motifs CRE/ATF. These proteins regulate transcription after cAMP- dependent phosphorylation (CREB), or interaction with the adenovirus E1A oncoprotein (ATF-2). Subtle modulation might be further attained by the cross-talk between the different signal-transduction pathways and the heterodimerization of different classes of transcription factors. The CREB/ATF transcription factors therefore exert a pleiotropic action during the integration of extra/intra cellular signals in the resulting adaptation of cellular responses. Dysregulation might be associated with pathological situations related to the uncontrolled cell proliferation, oncogenic progression and metastasis.

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August 1992
Volume 1 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MIROSSAY L, CHASTRE E, EMPEREUR S and GESPACH C: CYCLIC AMP-RESPONSIVE GENE-TRANSCRIPTION IN CELLULAR PROLIFERATION AND TRANSFORMATION. Int J Oncol 1: 373-385, 1992.
APA
MIROSSAY, L., CHASTRE, E., EMPEREUR, S., & GESPACH, C. (1992). CYCLIC AMP-RESPONSIVE GENE-TRANSCRIPTION IN CELLULAR PROLIFERATION AND TRANSFORMATION. International Journal of Oncology, 1, 373-385. https://doi.org/10.3892/ijo.1.3.373
MLA
MIROSSAY, L., CHASTRE, E., EMPEREUR, S., GESPACH, C."CYCLIC AMP-RESPONSIVE GENE-TRANSCRIPTION IN CELLULAR PROLIFERATION AND TRANSFORMATION". International Journal of Oncology 1.3 (1992): 373-385.
Chicago
MIROSSAY, L., CHASTRE, E., EMPEREUR, S., GESPACH, C."CYCLIC AMP-RESPONSIVE GENE-TRANSCRIPTION IN CELLULAR PROLIFERATION AND TRANSFORMATION". International Journal of Oncology 1, no. 3 (1992): 373-385. https://doi.org/10.3892/ijo.1.3.373