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THE TREATMENT OF COLORECTAL HEPATIC METASTASES BY CONTINUOUS LOCAL INFUSION OF INTERLEUKIN-2

  • Authors:
    • J HOLLINGWORTH
    • EM WATKIN
    • SS UBHI
    • T HORSBURGH
    • PS VEITCH
    • PRF BELL

  • View Affiliations

  • Published online on: October 1, 1992     https://doi.org/10.3892/ijo.1.5.607
  • Pages: 607-610
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Patients with hepatic metastases from colorectal cancer appear to be resistant to most forms of therapy. Recent reports suggest synergism between systemically administered recombinant interleukin-2 (rIL-2) and 5-fluorouracil (5-FU) with responses documented in the treatment of advanced colonic tumours albeit with significant toxicity. Local continuous infusion of rIL-2 into selected sites may reduce toxicity and increase efficacy. We have assessed the feasibility of continuously infusing rIL-2 into the region of a hepatic metastasis in 3 patients via a catheter placed within the liver under ultrasound guidance in a regimen including systemic rIL-2 and 5FU.

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October 1992
Volume 1 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
HOLLINGWORTH J, WATKIN E, UBHI S, HORSBURGH T, VEITCH P and BELL P: THE TREATMENT OF COLORECTAL HEPATIC METASTASES BY CONTINUOUS LOCAL INFUSION OF INTERLEUKIN-2. Int J Oncol 1: 607-610, 1992
APA
HOLLINGWORTH, J., WATKIN, E., UBHI, S., HORSBURGH, T., VEITCH, P., & BELL, P. (1992). THE TREATMENT OF COLORECTAL HEPATIC METASTASES BY CONTINUOUS LOCAL INFUSION OF INTERLEUKIN-2. International Journal of Oncology, 1, 607-610. https://doi.org/10.3892/ijo.1.5.607
MLA
HOLLINGWORTH, J., WATKIN, E., UBHI, S., HORSBURGH, T., VEITCH, P., BELL, P."THE TREATMENT OF COLORECTAL HEPATIC METASTASES BY CONTINUOUS LOCAL INFUSION OF INTERLEUKIN-2". International Journal of Oncology 1.5 (1992): 607-610.
Chicago
HOLLINGWORTH, J., WATKIN, E., UBHI, S., HORSBURGH, T., VEITCH, P., BELL, P."THE TREATMENT OF COLORECTAL HEPATIC METASTASES BY CONTINUOUS LOCAL INFUSION OF INTERLEUKIN-2". International Journal of Oncology 1, no. 5 (1992): 607-610. https://doi.org/10.3892/ijo.1.5.607