Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis

  • Authors:
    • S Tatsuta
    • S Tanaka
    • K Haruma
    • M Yoshihara
    • K Sumii
    • G Kajiyama
    • F Shimamoto
  • View Affiliations

  • Published online on: January 1, 1997     https://doi.org/10.3892/ijo.10.1.125
  • Pages: 125-129
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Abstract

To examine the relationship among the expression of urokinase-type plasminogen activator (u-PA), invasive/metastatic potential and prognosis of colorectal cancer (CRC), 58 patients with surgically resected advanced CRC were studied. u-PA expression and proliferating cell nuclear antigen labeling index (PCNA-LI) at the deepest invasive portion were examined immunohistochemically. u-PA expression was detected in 37 (63.8%) of 58 lesions. Lesions with liver metastasis showed a significantly (p < 0.01) higher incidence of u-PA expression than those without liver metastasis. Dukes staging also revealed a significant correlation with u-PA expression. The combination of u-PA expression and elevated PCNA-LI at the deepest invasive portion correlated significantly with prognosis. These results indicate that u-PA expression is an important predictor of CRC development and liver metastasis. Furthermore, combined analysis of u-PA expression and PCNA-LI at the deepest invasive portion is very useful in predicting CRC prognosis.

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January 1997
Volume 10 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tatsuta S, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G and Shimamoto F: Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis. Int J Oncol 10: 125-129, 1997.
APA
Tatsuta, S., Tanaka, S., Haruma, K., Yoshihara, M., Sumii, K., Kajiyama, G., & Shimamoto, F. (1997). Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis. International Journal of Oncology, 10, 125-129. https://doi.org/10.3892/ijo.10.1.125
MLA
Tatsuta, S., Tanaka, S., Haruma, K., Yoshihara, M., Sumii, K., Kajiyama, G., Shimamoto, F."Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis". International Journal of Oncology 10.1 (1997): 125-129.
Chicago
Tatsuta, S., Tanaka, S., Haruma, K., Yoshihara, M., Sumii, K., Kajiyama, G., Shimamoto, F."Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis". International Journal of Oncology 10, no. 1 (1997): 125-129. https://doi.org/10.3892/ijo.10.1.125