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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1997 Volume 10 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1997 Volume 10 Issue 2

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Article

The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells

  • Authors:
    • M Caligo
    • A Bellachene
    • G Cipollini
    • G Bevilacqua
    • V Castronovo

  • View Affiliations / Copyright

    Affiliations: UNIV LIEGE,METASTASIS RES LAB,LIEGE,BELGIUM.
  • Pages: 253-256
    |
    Published online on: February 1, 1997
       https://doi.org/10.3892/ijo.10.2.253
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Abstract

BRCA1 has been characterized as one of the major breast cancer susceptibility genes. Although no BRCA1 mutations have been reported in sporadic breast cancer, altered levels of BRCA1 are found in non hereditary breast malignant lesions. Therefore, BRCA1 is potentially playing a key role in the genesis of breast cancer. In this study, we explored the effects of estradiol and two differentiating agents, the progestin ORG2058 and retinoic acid, on BRCA1 mRNA expression in human estrogen and progesterone receptor positive MCF-7 cells. Using RNAse protection assay, we have demonstrated that ORG2058 induces a major (50 times) stimulation of BRCA1 mRNA expression. The maximum induction effect was obtained at the pharmacological dose of 100 nM and after 48 h of treatment. While estradiol generated an expected increase of BRCA1 mRNA, retinoic acid did not produce any effects. Our results demonstrate for the first time that BRCA1 is specifically up-regulated by a progestin, a steroid known to induce the differentiation of epithelial mammary cells. The absence of retinoic acid effect suggests that a specific progesterone-dependent pathway, could control BRCA1 expression.

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Copy and paste a formatted citation
Spandidos Publications style
Caligo M, Bellachene A, Cipollini G, Bevilacqua G and Castronovo V: The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells. Int J Oncol 10: 253-256, 1997.
APA
Caligo, M., Bellachene, A., Cipollini, G., Bevilacqua, G., & Castronovo, V. (1997). The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells. International Journal of Oncology, 10, 253-256. https://doi.org/10.3892/ijo.10.2.253
MLA
Caligo, M., Bellachene, A., Cipollini, G., Bevilacqua, G., Castronovo, V."The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells". International Journal of Oncology 10.2 (1997): 253-256.
Chicago
Caligo, M., Bellachene, A., Cipollini, G., Bevilacqua, G., Castronovo, V."The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells". International Journal of Oncology 10, no. 2 (1997): 253-256. https://doi.org/10.3892/ijo.10.2.253
Copy and paste a formatted citation
x
Spandidos Publications style
Caligo M, Bellachene A, Cipollini G, Bevilacqua G and Castronovo V: The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells. Int J Oncol 10: 253-256, 1997.
APA
Caligo, M., Bellachene, A., Cipollini, G., Bevilacqua, G., & Castronovo, V. (1997). The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells. International Journal of Oncology, 10, 253-256. https://doi.org/10.3892/ijo.10.2.253
MLA
Caligo, M., Bellachene, A., Cipollini, G., Bevilacqua, G., Castronovo, V."The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells". International Journal of Oncology 10.2 (1997): 253-256.
Chicago
Caligo, M., Bellachene, A., Cipollini, G., Bevilacqua, G., Castronovo, V."The progestin ORG2058 but not retinoic acid stimulates BRCA1 mRNA expression in MCF-7 human breast cancer cells". International Journal of Oncology 10, no. 2 (1997): 253-256. https://doi.org/10.3892/ijo.10.2.253
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