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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1997 Volume 10 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1997 Volume 10 Issue 3

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Article

In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis

  • Authors:
    • M Rocha
    • V Umansky
    • V Schirrmacher
    • M Elices

  • View Affiliations / Copyright

    Affiliations: CYTEL CORP, SAN DIEGO, CA 92121 USA.
  • Pages: 457-464
    |
    Published online on: March 1, 1997
       https://doi.org/10.3892/ijo.10.3.457
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Abstract

The role of VLA-4 integrin in liver metastasis of lymphoma cells was investigated. ESbL-lacZ lymphoma cells in vitro exhibited high surface expression of VLA-4, adhered to CS-1 fibronectin and VCAM-1 and cell adhesion was inhibited by anti-VLA-4 MAb PS/2. When injected in vivo, however, PS/2 did not interfere with spontaneous liver metastasis and had no effect on survival. Ex vivo analysis of VLA-4 surface expression was facilitated by a new reisolation method for tumor and host cells derived from metastatic target organs. Freshly ex vivo isolated tumor cells from metastatic livers revealed VLA-4 surface downregulation as early as 3 days after tumor injection, which continued during the course of metastasis. VLA-4 downregulation in liver metastasis was also seen at the mRNA transcriptional level. Primary tumor cells showed similar VLA-4 downregulation suggesting that the in vivo phenotype was induced by the microenvironment at the primary tumor site. In support of this hypothesis, re-isolated tumor cells from metastatic livers recovered the high VLA-4 expression in host-depleted cell cultures. This study suggests that VLA-4 expression on tumor cells can be modulated in situ during tumor growth and metastasis formation.

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Copy and paste a formatted citation
Spandidos Publications style
Rocha M, Umansky V, Schirrmacher V and Elices M: In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis. Int J Oncol 10: 457-464, 1997.
APA
Rocha, M., Umansky, V., Schirrmacher, V., & Elices, M. (1997). In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis. International Journal of Oncology, 10, 457-464. https://doi.org/10.3892/ijo.10.3.457
MLA
Rocha, M., Umansky, V., Schirrmacher, V., Elices, M."In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis". International Journal of Oncology 10.3 (1997): 457-464.
Chicago
Rocha, M., Umansky, V., Schirrmacher, V., Elices, M."In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis". International Journal of Oncology 10, no. 3 (1997): 457-464. https://doi.org/10.3892/ijo.10.3.457
Copy and paste a formatted citation
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Spandidos Publications style
Rocha M, Umansky V, Schirrmacher V and Elices M: In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis. Int J Oncol 10: 457-464, 1997.
APA
Rocha, M., Umansky, V., Schirrmacher, V., & Elices, M. (1997). In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis. International Journal of Oncology, 10, 457-464. https://doi.org/10.3892/ijo.10.3.457
MLA
Rocha, M., Umansky, V., Schirrmacher, V., Elices, M."In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis". International Journal of Oncology 10.3 (1997): 457-464.
Chicago
Rocha, M., Umansky, V., Schirrmacher, V., Elices, M."In situ downregulation of VLA-4 integrin cell surface expression during lymphoma growth and liver metastasis". International Journal of Oncology 10, no. 3 (1997): 457-464. https://doi.org/10.3892/ijo.10.3.457
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