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Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients

  • Authors:
    • G Bussolati
    • M Geuna
    • B Bussolati
    • M Millesimo
    • M Botta
    • A Bartorelli

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  • Published online on: April 1, 1997     https://doi.org/10.3892/ijo.10.4.779
  • Pages: 779-785
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Abstract

UK114 is a 14 kDa protein identified in the perchloric acid soluble extract of goat liver. Anti-UK114 antibodies identify this protein as expressed by the membrane of human cancer cells. In the present study, anti-UK114 antibodies were detected in the sera of cancer patients by ELISA and by immunofluorescence tests using human cancer cell lines as a target. UK114 protein is antigenic in cancer patients. Human anti-UK114 antibodies have cytolytic effects in vitro and their presence correlates with inhibition of growth of human carcinoma cells xenografted in nu/nu mice. This finding may open new prospects for immunotherapy.

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April 1997
Volume 10 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
Bussolati G, Geuna M, Bussolati B, Millesimo M, Botta M and Bartorelli A: Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients. Int J Oncol 10: 779-785, 1997
APA
Bussolati, G., Geuna, M., Bussolati, B., Millesimo, M., Botta, M., & Bartorelli, A. (1997). Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients. International Journal of Oncology, 10, 779-785. https://doi.org/10.3892/ijo.10.4.779
MLA
Bussolati, G., Geuna, M., Bussolati, B., Millesimo, M., Botta, M., Bartorelli, A."Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients". International Journal of Oncology 10.4 (1997): 779-785.
Chicago
Bussolati, G., Geuna, M., Bussolati, B., Millesimo, M., Botta, M., Bartorelli, A."Cytolytic and tumor inhibitory antibodies against UK114 protein in the sera of cancer patients". International Journal of Oncology 10, no. 4 (1997): 779-785. https://doi.org/10.3892/ijo.10.4.779