Markers of human T lymphotropic virus type I in patients with cancer of uterine cervix in Amazon, Brazil

  • Authors:
    • L Kanzaki
    • K Maruyama
    • T Fukushima
    • R TamezGuerra
    • L TrejoAvila
    • J Casseb
    • E Neitzert
    • J Macedo
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/ijo.10.5.1021
  • Pages: 1021-1024
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Abstract

Human T lymphotropic virus type I(HTLV-I) has been implicated in various human diseases. Serum samples of 390 Brazilian Amazonians with cancer of various types were tested for HTLV-I antibodies by Gelatin particle agglutination test, Enzyme linked immunosorbent assay and Western blotting. Of 134 sera from patients with cancer of uterine cervix, 4 were positive by all the methods. Three of these were from non-transfused patients. DNA was extracted from 2 of 4 seropositive sera that gave strong reactions and were analyzed by PCR-SSCP for HTLV-I sequences. One was positive for all HTLV-I genes tested while the other one was positive for LTR and tax and negative for gag. In view of a possible pathway of the virus by sexual contact, the involvement of HTLV-I in cervical cancer warrants further studies.

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May 1997
Volume 10 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kanzaki L, Maruyama K, Fukushima T, TamezGuerra R, TrejoAvila L, Casseb J, Neitzert E and Macedo J: Markers of human T lymphotropic virus type I in patients with cancer of uterine cervix in Amazon, Brazil. Int J Oncol 10: 1021-1024, 1997.
APA
Kanzaki, L., Maruyama, K., Fukushima, T., TamezGuerra, R., TrejoAvila, L., Casseb, J. ... Macedo, J. (1997). Markers of human T lymphotropic virus type I in patients with cancer of uterine cervix in Amazon, Brazil. International Journal of Oncology, 10, 1021-1024. https://doi.org/10.3892/ijo.10.5.1021
MLA
Kanzaki, L., Maruyama, K., Fukushima, T., TamezGuerra, R., TrejoAvila, L., Casseb, J., Neitzert, E., Macedo, J."Markers of human T lymphotropic virus type I in patients with cancer of uterine cervix in Amazon, Brazil". International Journal of Oncology 10.5 (1997): 1021-1024.
Chicago
Kanzaki, L., Maruyama, K., Fukushima, T., TamezGuerra, R., TrejoAvila, L., Casseb, J., Neitzert, E., Macedo, J."Markers of human T lymphotropic virus type I in patients with cancer of uterine cervix in Amazon, Brazil". International Journal of Oncology 10, no. 5 (1997): 1021-1024. https://doi.org/10.3892/ijo.10.5.1021