Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding

  • Authors:
    • T Nishi
    • H Takeshima
    • K Hamada
    • K Yoshizato
    • H Koga
    • K Sato
    • K Yamamoto
    • I Kitamura
    • M Kochi
    • J Kuratsu
    • H Saya
    • Y Ushio
  • View Affiliations

  • Published online on: May 1, 1997     https://doi.org/10.3892/ijo.10.5.1025
  • Pages: 1025-1029
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Abstract

Three novel isoforms of the neurofibromatosis 2 (NF2) gene transcripts generated from alternative splicing were identified from normal human brain, schwannoma and glioma tissues. The 3 novel transcripts lack exon 2, exons 2 and 3, exons 2-4, respectively. Recombinant isoform proteins encoded by those new transcripts have lost the previously reported ability to bind S-35-methionine labeled cellular proteins. Two of seven glioblastoma tissues expressed significantly high levels of the shorter transcripts whereas low grade astrocytomas expressed levels similar to those found in normal brain, suggesting that genomic mutation or aberrant alternative splicing of the NF2 gene may contribute to the progression of malignant gliomas.

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May 1997
Volume 10 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Nishi T, Takeshima H, Hamada K, Yoshizato K, Koga H, Sato K, Yamamoto K, Kitamura I, Kochi M, Kuratsu J, Kuratsu J, et al: Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding. Int J Oncol 10: 1025-1029, 1997.
APA
Nishi, T., Takeshima, H., Hamada, K., Yoshizato, K., Koga, H., Sato, K. ... Ushio, Y. (1997). Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding. International Journal of Oncology, 10, 1025-1029. https://doi.org/10.3892/ijo.10.5.1025
MLA
Nishi, T., Takeshima, H., Hamada, K., Yoshizato, K., Koga, H., Sato, K., Yamamoto, K., Kitamura, I., Kochi, M., Kuratsu, J., Saya, H., Ushio, Y."Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding". International Journal of Oncology 10.5 (1997): 1025-1029.
Chicago
Nishi, T., Takeshima, H., Hamada, K., Yoshizato, K., Koga, H., Sato, K., Yamamoto, K., Kitamura, I., Kochi, M., Kuratsu, J., Saya, H., Ushio, Y."Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding". International Journal of Oncology 10, no. 5 (1997): 1025-1029. https://doi.org/10.3892/ijo.10.5.1025