p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms

  • Authors:
    • T Oyama
    • T Kawamoto
    • T Mizoue
    • K Nishida
    • T Osaki
    • K Sugio
    • K Yasumoto
    • T Mitsudomi
  • View Affiliations

  • Published online on: August 1, 1997     https://doi.org/10.3892/ijo.11.2.305
  • Pages: 305-309
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Abstract

Cytochrome p4501A1 gene (CYP1A1) and glutathione S-transferase mu gene (GSTM1) are involved in the metabolic activation or detoxification of environmental carcinogens including benzo[a]pyrene in tobacco smoke. Individuals with both Val/Val and C type of CYP1A1 (CYP1A1; Val/Val and CYP1A1; C) or homozygous null (-/-) genotype of GSTM1 gene (GSTM1; -/-) show increased susceptibility to lung cancer. The incidence of p53 gene mutations are related to the smoking index of the lung cancer patients. Therefore we determined genotypes of these enzymes and screened p53 gene mutations in 123 non-small cell lung cancer (NSCLC) patients. p53 gene mutations were found in 35% (43/123) of the patients. The incidence of p53 gene mutation CYP1A1; Val/Val (60.0%), CYP1A1; C (50.0%) tended to be higher than those of CYPIAI; Ile/Ile and Ile/Val (40.4%) or CYP1A1; A and B (40.5%). We conclude that the incidence of the p53 mutations does not seem to be significantly affected by only CYP1A1 or GSTM1 polymorphisms in lung cancer patients.

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August 1997
Volume 11 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Oyama T, Kawamoto T, Mizoue T, Nishida K, Osaki T, Sugio K, Yasumoto K and Mitsudomi T: p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. Int J Oncol 11: 305-309, 1997
APA
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K. ... Mitsudomi, T. (1997). p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms. International Journal of Oncology, 11, 305-309. https://doi.org/10.3892/ijo.11.2.305
MLA
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K., Yasumoto, K., Mitsudomi, T."p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms". International Journal of Oncology 11.2 (1997): 305-309.
Chicago
Oyama, T., Kawamoto, T., Mizoue, T., Nishida, K., Osaki, T., Sugio, K., Yasumoto, K., Mitsudomi, T."p53 mutations of lung cancer are not significantly affected by CYP1A1 or GSTM1 polymorphisms". International Journal of Oncology 11, no. 2 (1997): 305-309. https://doi.org/10.3892/ijo.11.2.305