Structure and function of plasminogen activator inhibitor-2

  • Authors:
    • P Jensen
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  • Published online on: September 1, 1997     https://doi.org/10.3892/ijo.11.3.557
  • Pages: 557-570
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Abstract

Serine proteinase inhibitors (serpins) are well known regulators of extracellular proteolytic pathways. A recently identified group of intracellular serpins of mammalian and viral origin, designated ovalbumine-like serpins, modify intracellular proteolytic pathways involved in the regulation of apoptosis and inflammation. This review focuses on plasminogen activator inhibitor-2 (PAI-2) in terms of the molecular structure-function relationships and its intracellular functions, in particular in relation to apoptosis. PAI-2 inhibits apoptosis in cell lines challenged with tumor necrosis factor or certain viruses. The intracellular proteinases which PAI-2 act upon are still unknown. During myeloid apoptosis, PAI-2 proteolytically modified to a smaller but still proteinase inhibitory form. PAI-2 is unique among the serpins with respect to its large CD-domain localized between alpha-helices C and D. Recent data show that two domains in PAI-2 are required for its antiapoptotic activity, the CD-domain and the proteinase reactive site. We have shown the CD-domain is involved in covalent and reversible interactions with cytosolic proteins, e.g. the annexins. These intracellular PAI-2-reactive proteins might represent participants in signalling pathways involved in the regulation of cell survival.

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September 1997
Volume 11 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Jensen P: Structure and function of plasminogen activator inhibitor-2. Int J Oncol 11: 557-570, 1997
APA
Jensen, P. (1997). Structure and function of plasminogen activator inhibitor-2. International Journal of Oncology, 11, 557-570. https://doi.org/10.3892/ijo.11.3.557
MLA
Jensen, P."Structure and function of plasminogen activator inhibitor-2". International Journal of Oncology 11.3 (1997): 557-570.
Chicago
Jensen, P."Structure and function of plasminogen activator inhibitor-2". International Journal of Oncology 11, no. 3 (1997): 557-570. https://doi.org/10.3892/ijo.11.3.557