Expression of bcl-2 protein in nephroblastomas

  • Authors:
    • D Govender
    • P Harilal
    • L Hadley
    • R Chetty
  • View Affiliations

  • Published online on: September 1, 1997     https://doi.org/10.3892/ijo.11.3.629
  • Pages: 629-633
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Abstract

Bcl-2 expression has been shown to relate to prognosis in several neoplasms. A study of 139 cases of nephroblastomas was undertaken to ascertain the prognostic value of bcl-2 immunoexpression. Archival formalin-fixed, paraffin-embedded tissue sections were stained with monoclonal anti-bcl-2 antibody using a peroxidase-labelled streptavidin biotin kit. 75.5% of cases showed bcl-2 immunoreactivity, however, heterogeneous staining was observed within each case. No statistically significant correlation was found when bcl-2 expression was compared to histology (P=0.451), disease status (P=0.375) and disease stage (P=0.875). A statistically significant difference in bcl-2 protein was noted when comparing tumours treated with and those not treated with pre-operative chemotherapy (P=0.002). Further analysis of the cases that were treated with pre-operative chemotherapy showed a striking difference in survival periods between bcl-2 positive (shorter) and negative tumours (longer). Although not statistically significant, we think that this finding requires further investigation in other series. The results of bcl-2 immunoexpression in nephroblastomas may have prognostic implications that impact on patient treatment protocols.

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September 1997
Volume 11 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Govender D, Harilal P, Hadley L and Chetty R: Expression of bcl-2 protein in nephroblastomas. Int J Oncol 11: 629-633, 1997
APA
Govender, D., Harilal, P., Hadley, L., & Chetty, R. (1997). Expression of bcl-2 protein in nephroblastomas. International Journal of Oncology, 11, 629-633. https://doi.org/10.3892/ijo.11.3.629
MLA
Govender, D., Harilal, P., Hadley, L., Chetty, R."Expression of bcl-2 protein in nephroblastomas". International Journal of Oncology 11.3 (1997): 629-633.
Chicago
Govender, D., Harilal, P., Hadley, L., Chetty, R."Expression of bcl-2 protein in nephroblastomas". International Journal of Oncology 11, no. 3 (1997): 629-633. https://doi.org/10.3892/ijo.11.3.629