Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension

  • Authors:
    • Y Aoki
    • K Akagi
    • T Oshima
    • H Isoda
    • R Nasu
    • T Shiga
    • T Murata
    • Y Tanaka
  • View Affiliations

  • Published online on: November 1, 1997     https://doi.org/10.3892/ijo.11.5.1123
  • Pages: 1123-1128
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Abstract

We investigated changes in blood flow in normal muscle and in SCC-VII tumors treated by hyperthermia combined with hydralazine, to evaluate the enhancement of thermal tumor damage by hydralazine. We studied SCC-VII tumor-bearing C3H/He mice. Hydralazine was administered by intraperitoneal injection, and tumors were heated by a water bath. We measured blood flow using the laser Doppler method, and oxygen tension using polarography. The response of tumors to therapy was assessed using a growth delay analysis. In tumors, blood flow and O-2 tension significantly decreased with increasing doses of hydralazine. Compared to tumors treated by hydralazine alone or by hyperthermia alone, tumor blood flow was significantly decreased in the group treated by hyperthermia with hydralazine. In tumors treated by hyperthermia with hydralazine, blood flow was significantly decreased with increasing Hyd doses, heat durations, and temperatures. In normal muscle, no decrease in blood flow was induced by hyperthermia, hydralazine, or their combination. In tumors treated by hyperthermia (43 degrees C, 20 min) with hydralazine, a maximum additional growth delay was observed. Our results suggest that a decrease in tumor blood flow caused by hydralazine plays an important role in enhancement of the hyperthermic antitumor effect.

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November 1997
Volume 11 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Aoki Y, Akagi K, Oshima T, Isoda H, Nasu R, Shiga T, Murata T and Tanaka Y: Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension. Int J Oncol 11: 1123-1128, 1997
APA
Aoki, Y., Akagi, K., Oshima, T., Isoda, H., Nasu, R., Shiga, T. ... Tanaka, Y. (1997). Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension. International Journal of Oncology, 11, 1123-1128. https://doi.org/10.3892/ijo.11.5.1123
MLA
Aoki, Y., Akagi, K., Oshima, T., Isoda, H., Nasu, R., Shiga, T., Murata, T., Tanaka, Y."Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension". International Journal of Oncology 11.5 (1997): 1123-1128.
Chicago
Aoki, Y., Akagi, K., Oshima, T., Isoda, H., Nasu, R., Shiga, T., Murata, T., Tanaka, Y."Enhancement of thermal damage in murine tumors by hydralazine-induced modification of blood flow and oxygen tension". International Journal of Oncology 11, no. 5 (1997): 1123-1128. https://doi.org/10.3892/ijo.11.5.1123