Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.

  • Authors:
    • H Nagayasu
    • J Hamada
    • D Nakata
    • T Shibata
    • M Kobayashi
    • M Hosokawa
    • N Takeichi
  • View Affiliations

  • Published online on: Thursday, January 1, 1998
  • Pages: 197-399 DOI: 10.3892/ijo.12.1.197

Abstract

We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was reversible, when the cells were pretreated with EGF for 24 h, whereas it was irreversible when pretreated with EGF for 1 month. EGF treatment elevated the intracellular peroxide level in ER-1 cells. When ER-1 cells were treated with EGF in the presence of N-acetylcysteine, a chemical antioxidant, the reversible or irreversible EGF-induced progression was inhibited. These results suggest that the reversible or irreversible tumor progression in ER-1 cells occur in accordance with the duration of exposure to EGF, and that reactive oxygen species may be involved in the progression.

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January 1998
Volume 12 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2015 Impact Factor: 3.018
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APA
Nagayasu, H., Hamada, J., Nakata, D., Shibata, T., Kobayashi, M., Hosokawa, M., & Takeichi, N. (1998). Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.. International Journal of Oncology, 12, 197-399. http://dx.doi.org/10.3892/ijo.12.1.197
MLA
Nagayasu, H., Hamada, J., Nakata, D., Shibata, T., Kobayashi, M., Hosokawa, M., Takeichi, N."Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.". International Journal of Oncology 12.1 (1998): 197-399.
Chicago
Nagayasu, H., Hamada, J., Nakata, D., Shibata, T., Kobayashi, M., Hosokawa, M., Takeichi, N."Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.". International Journal of Oncology 12, no. 1 (1998): 197-399. http://dx.doi.org/10.3892/ijo.12.1.197