Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.

  • Authors:
    • H Takei
    • Y Iino
    • J Horiguchi
    • M Maemura
    • Y Koibuchi
    • H Nagaoka
    • T Yokoe
    • T Oyama
    • Y Morishita
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.517
  • Pages: 517-540
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Abstract

Angiogenesis and stromal fibronectin (SFN) expression were immunohistochemically analyzed in 83 breast cancer specimens. Microvessel count (MVC), which correlated with lymph node metastasis, TNM stage, recurrence, and mortality, was relatively low in SFN-positive tumors. SFN expression did not correlate with lymph node metastases or tumor size. However, SFN positivity was less likely in patients with recurrent disease than in those without recurrence, and relapse-free survival was significantly better in patients with SFN-positive tumors than in those with SFN-negative tumors. MVC and SFN positivity were significant independent predictors of relapse-free survival as well as tumor size and axillary nodal status (Cox's proportional hazards regression analysis). Angiogenesis and SFN expression, both of which are inversely related, can be used prognostically in patients with breast cancer.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Takei H, Iino Y, Horiguchi J, Maemura M, Koibuchi Y, Nagaoka H, Yokoe T, Oyama T and Morishita Y: Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.. Int J Oncol 12: 517-540, 1998.
APA
Takei, H., Iino, Y., Horiguchi, J., Maemura, M., Koibuchi, Y., Nagaoka, H. ... Morishita, Y. (1998). Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.. International Journal of Oncology, 12, 517-540. https://doi.org/10.3892/ijo.12.3.517
MLA
Takei, H., Iino, Y., Horiguchi, J., Maemura, M., Koibuchi, Y., Nagaoka, H., Yokoe, T., Oyama, T., Morishita, Y."Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.". International Journal of Oncology 12.3 (1998): 517-540.
Chicago
Takei, H., Iino, Y., Horiguchi, J., Maemura, M., Koibuchi, Y., Nagaoka, H., Yokoe, T., Oyama, T., Morishita, Y."Angiogenesis and stromal fibronectin expression in invasive breast carcinoma.". International Journal of Oncology 12, no. 3 (1998): 517-540. https://doi.org/10.3892/ijo.12.3.517