Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours.

  • Authors:
    • K Mimori
    • M Mori
    • T Shiraishi
    • S Tanaka
    • M Haraguchi
    • H Ueo
    • C Shirasaka
    • T Akiyoshi
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.597
  • Pages: 597-1198
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Abstract

We examined the expression of ornithine decarboxylase (ODC) mRNA in 53 female cases of breast cancer by a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to determine the clinicopathologic significance of its expression. A significantly higher expression of ODC mRNA was, observed in younger patients than in older patients. The patients with a larger sized tumour possessed a significantly higher expression of ODC mRNA. In addition, the cases with a poor prognosis showed significantly higher expression of ODC. Previous studies have reported in vivo and in vitro correlation between the expression of ODC and c-myc genes in human carcinomas. We disclosed a significant correlation between these genes in primary breast carcinomas. We conclude that the expression of ODC may potentially be a new biological marker for breast carcinoma.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mimori K, Mori M, Shiraishi T, Tanaka S, Haraguchi M, Ueo H, Shirasaka C and Akiyoshi T: Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours.. Int J Oncol 12: 597-1198, 1998
APA
Mimori, K., Mori, M., Shiraishi, T., Tanaka, S., Haraguchi, M., Ueo, H. ... Akiyoshi, T. (1998). Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours.. International Journal of Oncology, 12, 597-1198. https://doi.org/10.3892/ijo.12.3.597
MLA
Mimori, K., Mori, M., Shiraishi, T., Tanaka, S., Haraguchi, M., Ueo, H., Shirasaka, C., Akiyoshi, T."Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours.". International Journal of Oncology 12.3 (1998): 597-1198.
Chicago
Mimori, K., Mori, M., Shiraishi, T., Tanaka, S., Haraguchi, M., Ueo, H., Shirasaka, C., Akiyoshi, T."Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours.". International Journal of Oncology 12, no. 3 (1998): 597-1198. https://doi.org/10.3892/ijo.12.3.597