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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Mar 1998 Volume 12 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Mar 1998 Volume 12 Issue 3

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Article

Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.

  • Authors:
    • T C Hsu
    • Y Zhao
    • R Y Wang
    • R Dickerson
    • J C Liang
    • X Wang
    • Y Wu

  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, The University of Texas, M.D. Anderson Cancer Center, Box 181, Houston, Texas 77030, USA.
  • Pages: 617-637
    |
    Published online on: March 1, 1998
       https://doi.org/10.3892/ijo.12.3.617
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Abstract

In a breast cancer cell line, MDA-MB-468, established in our laboratory, an average of 3% of the mitotic cells exhibited a phenomenon known as centromere splaying, which is a characteristic feature of cells of patients with Roberts syndrome. However, centromere splaying in cells of Roberts syndrome patients is limited to i) the centromere region and ii) chromosomes with large amounts of heterochromatin. When the breast cancer cells were treated with an extract of green tea GTE-TP91, up to 45% of the metaphases were observed to exhibit this behavior; and the precocious centromere separation was highly exaggerated, affecting all chromosomes in such metaphases. Apparently, as the sister centromeres continued to pull apart, they carried the chromatids with them, except for the telomere regions, giving a ring-like configuration. Eventually, the sister chromatids became completely separated. Whether this bizarre phenomenon was induced by the polyphenols contained in this green tea extract GTE-TP91 is not known, but this phenomenon, upon further investigation, may throw some light on chromosomal proteins, centromere behavior, telomere behavior and related questions.

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Copy and paste a formatted citation
Spandidos Publications style
Hsu T, Zhao Y, Wang R, Dickerson R, Liang J, Wang X and Wu Y: Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.. Int J Oncol 12: 617-637, 1998.
APA
Hsu, T., Zhao, Y., Wang, R., Dickerson, R., Liang, J., Wang, X., & Wu, Y. (1998). Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.. International Journal of Oncology, 12, 617-637. https://doi.org/10.3892/ijo.12.3.617
MLA
Hsu, T., Zhao, Y., Wang, R., Dickerson, R., Liang, J., Wang, X., Wu, Y."Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.". International Journal of Oncology 12.3 (1998): 617-637.
Chicago
Hsu, T., Zhao, Y., Wang, R., Dickerson, R., Liang, J., Wang, X., Wu, Y."Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.". International Journal of Oncology 12, no. 3 (1998): 617-637. https://doi.org/10.3892/ijo.12.3.617
Copy and paste a formatted citation
x
Spandidos Publications style
Hsu T, Zhao Y, Wang R, Dickerson R, Liang J, Wang X and Wu Y: Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.. Int J Oncol 12: 617-637, 1998.
APA
Hsu, T., Zhao, Y., Wang, R., Dickerson, R., Liang, J., Wang, X., & Wu, Y. (1998). Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.. International Journal of Oncology, 12, 617-637. https://doi.org/10.3892/ijo.12.3.617
MLA
Hsu, T., Zhao, Y., Wang, R., Dickerson, R., Liang, J., Wang, X., Wu, Y."Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.". International Journal of Oncology 12.3 (1998): 617-637.
Chicago
Hsu, T., Zhao, Y., Wang, R., Dickerson, R., Liang, J., Wang, X., Wu, Y."Exaggerated precocious centromere separation in cells of a human breast cancer line treated with a green tea extract.". International Journal of Oncology 12, no. 3 (1998): 617-637. https://doi.org/10.3892/ijo.12.3.617
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