AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis.

  • Authors:
    • D A Liebermann
    • B Gregory
    • B Hoffman
  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/ijo.12.3.685
  • Pages: 685-1385
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Abstract

A combination of in vitro and in vivo molecular genetic approaches have provided evidence to suggest that AP-1 (Fos/Jun) transcription factors play multiple roles in functional development of hematopoietic precursor cells into mature blood cells along most, if not all, of the hematopoietic cell lineages. This includes the monocyte/macrophage, granulocyte, megakaryocyte, mastocyte and erythroid lineages. In addition, studies using c-fos knockout mice have established a unique role for Fos, as a member of the AP-1 transcription factor complex, in determining the differentiation and activity of progenitors of the osteoclast lineage, a population of bone-forming cells which are of hematopoietic origin as well. Evidence has also accumulated to implicate AP-1 (Fos/Jun) transcription factor complexes as both positive and negative modulators of distinct apoptotic pathways in many cell types, including cells of hematopoietic origin. Fos/Jun have been implicated as positive modulators of apoptosis induced in hematopoietic progenitor cells of the myeloid lineage, a function that may relate to the control of blood cell homeostasis, as well as in programmed cell death associated with terminal differentiation of many other cell types, and apoptosis associated with withdrawal of growth/survival factors. On the other hand, the study of apoptosis induced in mammalian cells has implicated AP-1 in the protection against apoptosis induced by DNA-damaging agents. However, evidence to the contrary has been obtained as well, suggesting that AP-1 may function to modulate stress-induced apoptosis either positively or negatively, depending on the microenvironment and the cell type in which the stress stimulus is induced.

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Mar 1998
Volume 12 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Liebermann D, Gregory B and Hoffman B: AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis.. Int J Oncol 12: 685-1385, 1998
APA
Liebermann, D., Gregory, B., & Hoffman, B. (1998). AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis.. International Journal of Oncology, 12, 685-1385. https://doi.org/10.3892/ijo.12.3.685
MLA
Liebermann, D., Gregory, B., Hoffman, B."AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis.". International Journal of Oncology 12.3 (1998): 685-1385.
Chicago
Liebermann, D., Gregory, B., Hoffman, B."AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis.". International Journal of Oncology 12, no. 3 (1998): 685-1385. https://doi.org/10.3892/ijo.12.3.685