Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.

  • Authors:
    • J J Hu
    • J Y Hong
    • M A Lea
    • C S Yang
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijo.12.5.1049
  • Pages: 1049-1102
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The objective of this investigation was to determine if the decrease of cytochrome P4502E1 (CYP2E1) in hepatomas is related to the tumor growth rate. There was a significant correlation between N-nitrosodimethylamine (NDMA) demethylase activities and CYP2E1 protein levels in rat liver and hepatomas. The levels of NDMA demethylase activities and CYP2E1 protein content were lower in hepatomas than in the corresponding host livers. NDMA demethylase activities and CYP2E1 protein levels were greater in hepatomas of slow and intermediate growth rate than in fast growing hepatomas. A similar trend was also observed with CYP2E1 mRNA levels. The results demonstrated an inverse relationship between growth rate of rat hepatomas and the expression of CYP2E1.

Related Articles

Journal Cover

May 1998
Volume 12 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hu J, Hong J, Lea M and Yang C: Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.. Int J Oncol 12: 1049-1102, 1998
APA
Hu, J., Hong, J., Lea, M., & Yang, C. (1998). Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.. International Journal of Oncology, 12, 1049-1102. https://doi.org/10.3892/ijo.12.5.1049
MLA
Hu, J., Hong, J., Lea, M., Yang, C."Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.". International Journal of Oncology 12.5 (1998): 1049-1102.
Chicago
Hu, J., Hong, J., Lea, M., Yang, C."Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats.". International Journal of Oncology 12, no. 5 (1998): 1049-1102. https://doi.org/10.3892/ijo.12.5.1049