Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.

  • Authors:
    • H Yoshida
    • H Enomoto
    • M Miyauchi
    • K Takenaga
    • M Tanabe
    • N Ohnuma
    • S Sakiyama
    • M Tagawa
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/ijo.12.5.1067
  • Pages: 1067-1138
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Abstract

We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-4 cells subcutaneously inoculated into immunocompetent A/J mice was retarded compared with that of wild-type cells and consequently, the survival of the A/J mice which received C1300/IL-4 cells was prolonged. In immunodeficient nude mice we observed accelerated growth rate of wild-type tumors in comparison with the tumors developed in A/J mice. In contrast, the tumor growth of C1300/IL-4 cells in nude mice was significantly suppressed and the growth was much slower than that of C1300/IL-4 cells inoculated in A/J mice. Thus, the secretion of IL-4 from tumor cells produced antitumor effect more efficiently in mature T cell-defective hosts than in immunocompetent mice. Our results suggest a possible clinical application of IL-4 expression in tumor cells via genetic manipulations especially in immunocompromised cancer patients.

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May 1998
Volume 12 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yoshida H, Enomoto H, Miyauchi M, Takenaga K, Tanabe M, Ohnuma N, Sakiyama S and Tagawa M: Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.. Int J Oncol 12: 1067-1138, 1998.
APA
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N. ... Tagawa, M. (1998). Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.. International Journal of Oncology, 12, 1067-1138. https://doi.org/10.3892/ijo.12.5.1067
MLA
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N., Sakiyama, S., Tagawa, M."Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.". International Journal of Oncology 12.5 (1998): 1067-1138.
Chicago
Yoshida, H., Enomoto, H., Miyauchi, M., Takenaga, K., Tanabe, M., Ohnuma, N., Sakiyama, S., Tagawa, M."Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.". International Journal of Oncology 12, no. 5 (1998): 1067-1138. https://doi.org/10.3892/ijo.12.5.1067