p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.

  • Authors:
    • N S Prabhu
    • K Somasundaram
    • K Satyamoorthy
    • M Herlyn
    • W S El-Deiry
  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/ijo.13.1.5
  • Pages: 5-14
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Abstract

Human papillomavirus (HPV) is the major cause of cervical cancer worldwide. HPV-E6 protein targets the p53 tumor suppressor protein for degradation by ubiquitin-mediated proteolysis making such cancers resistant to p53-gene therapy. Here we show that infection of human cancer cells by E6-expressing adenovirus (Ad-E6) leads to degradation of both wild-type or mutant p53 protein. Interestingly, the p53-homologue candidate tumor suppressor p73 is not degraded in Ad-E6 infected cancer cells. Wild-type p73beta and not wild-type p53 or mutant p73 is a potent inhibitor of cancer colony growth and inducer of apoptosis, despite HPV-E6 overexpression. The results suggest a novel strategy using p73beta in gene therapy of HPV-E6 expressing cancers.

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Jul 1998
Volume 13 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Prabhu N, Somasundaram K, Satyamoorthy K, Herlyn M and El-Deiry W: p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.. Int J Oncol 13: 5-14, 1998
APA
Prabhu, N., Somasundaram, K., Satyamoorthy, K., Herlyn, M., & El-Deiry, W. (1998). p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.. International Journal of Oncology, 13, 5-14. https://doi.org/10.3892/ijo.13.1.5
MLA
Prabhu, N., Somasundaram, K., Satyamoorthy, K., Herlyn, M., El-Deiry, W."p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.". International Journal of Oncology 13.1 (1998): 5-14.
Chicago
Prabhu, N., Somasundaram, K., Satyamoorthy, K., Herlyn, M., El-Deiry, W."p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells.". International Journal of Oncology 13, no. 1 (1998): 5-14. https://doi.org/10.3892/ijo.13.1.5