Prognostic value of tumor cell proliferation and intratumor microvessel density in advanced gastric cancer treated with curative surgery.

Isozaki,H; Fujii,K; Nomura,E; Mabuchi,H; Hara,H; Sako,S; Nishiguchi,K; Ohtani,M; Tenjo,T; Nohara,T; Tanigawa,N

doi:10.3892/ijo.13.2.255

Prognostic value of tumor cell proliferation and intratumor microvessel density in advanced gastric cancer treated with curative surgery.

Authors:
- H Isozaki
- K Fujii
- E Nomura
- H Mabuchi
- H Hara
- S Sako
- K Nishiguchi
- M Ohtani
- T Tenjo
- T Nohara
- N Tanigawa
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Affiliations: First Department of Surgery, Okayama University Medical School, Okayama 700-8558, Japan.
Published online on: August 1, 1998 https://doi.org/10.3892/ijo.13.2.255
Pages: 255-264

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Abstract

To clarify the prognostic value of tumor cell proliferation [proliferating cell nuclear antigen (PCNA)-positive rate assessed by anti-PCNA immunostaining] and intratumor microvessel density (/0.74 mm2, assessed by anti-CD34 immunostaining) in gastric cancer, 192 advanced gastric cancer patients who underwent curative surgery were investigated. Multivariate analysis showed that the following variables were significantly related to prognosis: age (P=0.029), depth of invasion (P=0.005), lymph node metastasis (P=0.006), lymphatic invasion (P=0.038), venous invasion (P=0.0005), PCNA-positive rate (P=0.049) and intratumor microvessel density (P=0. 011). In conclusion, tumor cell proliferation and intratumor microvessel density were independent prognostic factors in patients with advanced gastric cancer undergoing curative surgery.