Interaction of tomudex with radiation in vitro and in vivo.

  • Authors:
    • B A Teicher
    • G Ara
    • Y N Chen
    • A Recht
    • C N Coleman
  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/ijo.13.3.437
  • Pages: 437-479
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Abstract

The potential of the thymidylate synthase inhibitor, Tomudex to interact with ionizing radiation was assessed in vitro and in vivo in comparison with 5-fluorouracil. A concentration of 1 microM Tomudex decreased the shoulder of the radiation survival curves for normally oxygenated and hypoxic human HT-29 colon carcinoma cells and human SCC-25 head and neck squamous carcinoma cells, resulting in enhancement ratios of 10 and 2.8 for normally oxygenated and hypoxic HT-29 cells at 5 Gray, respectively, and enhancement ratios of 19.5 and 2.7 for normally oxygenated and hypoxic SCC-25 cell at 5 Gray, respectively. Two schedules of Tomudex administered to animals bearing the Lewis lung carcinoma resulted in additive tumor growth delay with the fractionated radiation therapy. In nude mice bearing the HT-29 colon carcinoma grown as a xenograft, administration of Tomudex daily for 5 days on a 1 or 2-week schedule resulted in increased tumor growth delay along with fractionated radiation therapy on the same schedules. However, administration of Tomudex intermittently on a 2-week schedule appeared to be more interactive with daily fractionated radiation therapy on the 2-week schedule. In each assay, the results obtained with Tomudex were equal to or exceeded those obtained with 5-fluorouracil. These findings indicate that clinical trial of Tomudex along with fractionated radiation therapy is warranted.

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Sep 1998
Volume 13 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Teicher B, Ara G, Chen Y, Recht A and Coleman C: Interaction of tomudex with radiation in vitro and in vivo.. Int J Oncol 13: 437-479, 1998.
APA
Teicher, B., Ara, G., Chen, Y., Recht, A., & Coleman, C. (1998). Interaction of tomudex with radiation in vitro and in vivo.. International Journal of Oncology, 13, 437-479. https://doi.org/10.3892/ijo.13.3.437
MLA
Teicher, B., Ara, G., Chen, Y., Recht, A., Coleman, C."Interaction of tomudex with radiation in vitro and in vivo.". International Journal of Oncology 13.3 (1998): 437-479.
Chicago
Teicher, B., Ara, G., Chen, Y., Recht, A., Coleman, C."Interaction of tomudex with radiation in vitro and in vivo.". International Journal of Oncology 13, no. 3 (1998): 437-479. https://doi.org/10.3892/ijo.13.3.437