In vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin.

  • Authors:
    • H Huynh
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  • Published online on: September 1, 1998     https://doi.org/10.3892/ijo.13.3.571
  • Pages: 571-576
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Abstract

Human chorionic gonadotropin (hCG) is a differentiating agent and chemopreventive in rat DMBA-induced breast carcinogenesis. Insulin-like growth factors (IGFs) are potent mitogens for breast cancer cells. We report that the administration of hCG to female rats resulted in a significant increase in serum IGFBP-3 levels at doses greater than 10 UI and a significant decrease in serum IGF-I levels. Northern blot analysis revealed that hCG inhibited hepatic and mammary IGF-I gene expression at doses greater than 10 UI. Mammary IGFBP-5 and IGFBP-2 gene expression significantly increased at high doses of hCG while IGFBP-4 slightly decreased. Treatments greater than 10 UI of hCG resulted in a significant suppression of mammary IGFBP-3 and IGF-I receptor expression. Since IGFs are potent mitogens and antiapoptotic agents for breast cancer, this newly described activity of hCG may contribute to its antiproliferative properties, particularly with regard to the differentiation and inhibition of mammary tumours seen in animal models.

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Sep 1998
Volume 13 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Huynh H: In vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin.. Int J Oncol 13: 571-576, 1998.
APA
Huynh, H. (1998). In vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin.. International Journal of Oncology, 13, 571-576. https://doi.org/10.3892/ijo.13.3.571
MLA
Huynh, H."In vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin.". International Journal of Oncology 13.3 (1998): 571-576.
Chicago
Huynh, H."In vivo regulation of the insulin-like growth factor system of mitogens by human chorionic gonadotropin.". International Journal of Oncology 13, no. 3 (1998): 571-576. https://doi.org/10.3892/ijo.13.3.571