Suppression of heat-induced p53 accumulation and activation by CDDP or x-rays in human glioblastoma cells.
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- Published online on: October 1, 1998 https://doi.org/10.3892/ijo.13.4.741
- Pages: 741-748
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Abstract
We showed that the prominent suppressions of heat-induced accumulation and activation of p53 by CDDP or X-rays were observed in A-172 cells, but not in T98G cells. In addition, the interactive hyperthermic enhancement of CDDP or X-ray cytotoxicity was observed in A-172 cells, but not in T98G cells. Our findings indicate that suppressions of heat-induced accumulation and activation of p53 by CDDP or X-rays contribute positively to an interactive hyperthermic enhancement of CDDP- or X-ray cytotoxicity.
