Role of the transcription factor AP-1 in melanoma differentiation (review).

  • Authors:
    • D C Kang
    • M Motwani
    • P B Fisher
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1117
  • Pages: 1117-1143
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Abstract

Although the molecular details remain to be elucidated, temporal changes in gene expression that result in discrete biochemical alterations and growth arrest are primary determinants of terminal cell differentiation. The control of gene expression is inextricably associated with proteins that can initiate or inhibit gene transcription. Specific genes contain within their promoter regions, DNA sequences that permit the binding of transactivating and transinhibiting proteins that can initiate or suppress transcription, respectively. Activating protein-1 (AP-1), a dimeric complex consisting of proteins encoded by the Jun and Fos gene families, is a transcription factor induced by a variety of signals, including those eliciting proliferation, differentiation and programmed cell death (apoptosis). We presently review the potential role of AP-1 proteins in differentiation with specific emphasis on melanoma differentiation.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kang D, Motwani M and Fisher P: Role of the transcription factor AP-1 in melanoma differentiation (review).. Int J Oncol 13: 1117-1143, 1998
APA
Kang, D., Motwani, M., & Fisher, P. (1998). Role of the transcription factor AP-1 in melanoma differentiation (review).. International Journal of Oncology, 13, 1117-1143. https://doi.org/10.3892/ijo.13.6.1117
MLA
Kang, D., Motwani, M., Fisher, P."Role of the transcription factor AP-1 in melanoma differentiation (review).". International Journal of Oncology 13.6 (1998): 1117-1143.
Chicago
Kang, D., Motwani, M., Fisher, P."Role of the transcription factor AP-1 in melanoma differentiation (review).". International Journal of Oncology 13, no. 6 (1998): 1117-1143. https://doi.org/10.3892/ijo.13.6.1117