Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer.

  • Authors:
    • K Maeda
    • Y Nishiguchi
    • N Onoda
    • H Otani
    • B Nakata
    • S Yamada
    • M Okuno
    • M Sowa
    • K H Chung
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1147
  • Pages: 1147-1198
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Abstract

At least four genes involved in DNA mismatch repair (MMR), hMSH2, hMLH1, hPMS1 and hPMS2, have been cloned and characterized. These genes have been demonstrated to be altered in the germline of patients with hereditary non-polyposis colorectal cancer (HNPCC). HNPCC is an autosomal dominant disease characterized by a preponderance of proximal colon, young age of onset, increased multiplicity, and improved stage-specific survival. In this study, we examined the expression of hMSH2 protein in sporadic colorectal cancer (CRC). As a result, the frequency of right-sided CRC and multiple CRCs were significantly higher in the patients with hMSH2-negative CRC than in those with hMSH2-positive CRC. The rate of p53 positivity was significantly lower in the hMSH2-negative tumours than that in the hMSH2-positive tumours. The disease-free survival rate tended to be higher in the patients with hMSH2-negative CRC than in the patients with hMSH2-positive CRC. Our findings suggest that both the clinicopathological and biological features of hMSH2-negative sporadic CRC seemed to be similar to those of HNPCC. To clarify the mechanism of carcinogenesis in HNPCC and sporadic CRC, further investigations of genetic alterations caused by MMR genes will be needed.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Maeda K, Nishiguchi Y, Onoda N, Otani H, Nakata B, Yamada S, Okuno M, Sowa M and Chung K: Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer.. Int J Oncol 13: 1147-1198, 1998
APA
Maeda, K., Nishiguchi, Y., Onoda, N., Otani, H., Nakata, B., Yamada, S. ... Chung, K. (1998). Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer.. International Journal of Oncology, 13, 1147-1198. https://doi.org/10.3892/ijo.13.6.1147
MLA
Maeda, K., Nishiguchi, Y., Onoda, N., Otani, H., Nakata, B., Yamada, S., Okuno, M., Sowa, M., Chung, K."Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer.". International Journal of Oncology 13.6 (1998): 1147-1198.
Chicago
Maeda, K., Nishiguchi, Y., Onoda, N., Otani, H., Nakata, B., Yamada, S., Okuno, M., Sowa, M., Chung, K."Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer.". International Journal of Oncology 13, no. 6 (1998): 1147-1198. https://doi.org/10.3892/ijo.13.6.1147