Treatment of advanced gastric cancer with 5-fluorouracil and cisplatin in combination with dipyridamole.

  • Authors:
    • S Kohnoe
    • Y Maehara
    • I Takahashi
    • Y Emi
    • H Baba
    • K Sugimachi
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1203
  • Pages: 1203-1209
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Abstract

We investigated the efficacy of combination chemo-therapy using 5-fluorouracil (5-FU), cisplatin (CDDP), and dipyridamole (DP), which is based on the concept of double biochemical modulation. Twenty-eight patients with advanced gastric cancer were treated with the simultaneous continuous intravenous (i.v.) infusion of 5-FU (800 mg/m2/day) and DP (4 mg/kg/day), and i.v. infusion of CDDP (20 mg/m2/day) for 5 days. The cycles were repeated every 4 weeks. Twelve patients (43%) had a partial response (PR), while stable disease (NC) occurred in 13 patients (46%), and progression (PD) in 3 patients (11%). An improved performance status was observed in 20 patients (71%). The carcinoembryonic antigen (CEA) level was markedly decreased in 75% of the CEA-positive patients. Toxicity was acceptable. The mean steady state plasma concentration of total DP was 6.40.5 microM, which thus seemed adequate to potentiate the cytotoxicity of 5-FU. The treatment regimen described herein thus appears to be effective, safe and well tolerated by patients with advanced gastric cancer.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kohnoe S, Maehara Y, Takahashi I, Emi Y, Baba H and Sugimachi K: Treatment of advanced gastric cancer with 5-fluorouracil and cisplatin in combination with dipyridamole.. Int J Oncol 13: 1203-1209, 1998
APA
Kohnoe, S., Maehara, Y., Takahashi, I., Emi, Y., Baba, H., & Sugimachi, K. (1998). Treatment of advanced gastric cancer with 5-fluorouracil and cisplatin in combination with dipyridamole.. International Journal of Oncology, 13, 1203-1209. https://doi.org/10.3892/ijo.13.6.1203
MLA
Kohnoe, S., Maehara, Y., Takahashi, I., Emi, Y., Baba, H., Sugimachi, K."Treatment of advanced gastric cancer with 5-fluorouracil and cisplatin in combination with dipyridamole.". International Journal of Oncology 13.6 (1998): 1203-1209.
Chicago
Kohnoe, S., Maehara, Y., Takahashi, I., Emi, Y., Baba, H., Sugimachi, K."Treatment of advanced gastric cancer with 5-fluorouracil and cisplatin in combination with dipyridamole.". International Journal of Oncology 13, no. 6 (1998): 1203-1209. https://doi.org/10.3892/ijo.13.6.1203