TGF-beta and FGF-trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells.

  • Authors:
    • S Dormann
    • G Bauer
  • View Affiliations

  • Published online on: December 1, 1998     https://doi.org/10.3892/ijo.13.6.1247
  • Pages: 1247-1299
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Abstract

Transforming growth factor (TGF)-beta as well as fibroblast growth factor (FGF) are able to trigger intercellular induction of apoptosis. Interaction of either cytokine with non-transformed cells results in the production and release of apoptosis inducing factor (AIF) which is specifically directed against transformed cells. In both cases, AIF production is inhibited by the antioxidant N-Acetylcysteine, indicating that similar or identical signalling pathways are utilized. Whereas TGF-beta sensitizes transformed cells by down modulation of their endogenous survival factors, FGF is devoid of a similar activity. Therefore TGF-beta triggers and enhances intercellular induction of apoptosis by interaction with non-transformed and transformed cells, whereas the activity of FGF is based only on the interaction with non-transformed cells.

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Dec 1998
Volume 13 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Dormann S and Bauer G: TGF-beta and FGF-trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells.. Int J Oncol 13: 1247-1299, 1998.
APA
Dormann, S., & Bauer, G. (1998). TGF-beta and FGF-trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells.. International Journal of Oncology, 13, 1247-1299. https://doi.org/10.3892/ijo.13.6.1247
MLA
Dormann, S., Bauer, G."TGF-beta and FGF-trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells.". International Journal of Oncology 13.6 (1998): 1247-1299.
Chicago
Dormann, S., Bauer, G."TGF-beta and FGF-trigger intercellular induction of apoptosis: analogous activity on non-transformed but differential activity on transformed cells.". International Journal of Oncology 13, no. 6 (1998): 1247-1299. https://doi.org/10.3892/ijo.13.6.1247